Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014
Revenues:
Product sales	$ 15,321	$ 11,376	$ 13,064
Research and development revenues	31,316	25,599	14,945
Revenue sharing arrangement	2,200	4,829	7,298
Total revenues	48,837	41,804	35,307
Costs and operating expenses:
Cost of product sales	9,753	6,586	9,726
Research and development	22,229	20,673	22,755
Selling, general and administrative	25,419	22,315	21,937
Total costs and operating expenses	57,401	49,574	54,418
Loss from operations	(8,564)	(7,770)	(19,111)
Interest income	60	19	18
Other expense	(94)	(168)	(234)
Loss before income taxes	(8,598)	(7,919)	(19,327)
Benefit from income taxes	(40)	(338)	(256)
Net loss	$ (8,558)	$ (7,581)	$ (19,071)
Net loss per share of common stock, basic and diluted (usd per share)	$ (0.21)	$ (0.19)	$ (0.50)
Weighted average common shares used in computing net loss per share of common stock, basic and diluted (shares)	40,629	39,438	38,209