Basis of Presentation and Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2015

Accounting Policies [Abstract]

Schedule of estimated ranges of useful lives of property and equipment

Property, equipment and leasehold improvements are stated at cost less accumulated depreciation and amortization and depreciated using the straight-line method over their estimated useful lives as follows:

Asset classification	Estimated useful life
Laboratory equipment	5 years
Computer equipment and software	3 to 5 years
Office equipment and furniture	5 years
Leasehold improvements	Lesser of useful life or lease term

Property and equipment, net consisted of the following (in thousands):

	December 31,
	2015			2014
Laboratory equipment	$	20,503		$	23,002
Leasehold improvements	10,369			9,773
Computer equipment and software	3,271			3,262
Office equipment and furniture	1,178			1,227
Construction in progress (1)	3			24
Property and equipment	35,324			37,288
Less: accumulated depreciation and amortization	(32,215		)	(31,452		)
Impairment of laboratory equipment	—			(1,841		)
Property and equipment, net	$	3,109		$	3,995

(1) Construction in progress includes equipment received but not yet placed into service pending installation.