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Current assets (normally turning over within one year or one business cycle if longer) that are held for sale apart from normal operations and anticipated to be sold within one year.

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The amount by which the fair value of an investment in debt and equity securities categorized as Available-for-sale is less than the amortized cost basis or carrying amount of that investment at the balance sheet date and the decline in fair value is deemed to be other than temporary, before considering whether or not such amount is recognized in earnings or other comprehensive income.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name FASB Staff Position (FSP)

-Number FAS115-1/124-1

-Paragraph 15D

-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name FASB Staff Position (FSP)

-Number FAS115-1/124-1

-Paragraph 15C

-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 3: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name FASB Staff Position (FSP)

-Number FAS115-1/124-1

-Paragraph 22

-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

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Data Type:	xbrli:monetaryItemType
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Period Type:	duration

- Definition

This item represents the total realized gain (loss) included in earnings for the period as a result of selling marketable securities categorized as trading, available-for-sale, or held-to-maturity and any gains or losses realized during the period from the sale of investments accounted for under the cost method of accounting and/or investments that are separately or otherwise not categorized as trading, available-for-sale, or held-to-maturity. Additionally, this item would include any losses recognized for other than temporary impairments (OTTI) of the subject investments in debt and equity securities.

+ References

No definition available.

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Balance Type:	credit
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- Definition

The cumulative amount of the reporting entity's undistributed earnings or deficit.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher AICPA

-Name Accounting Principles Board Opinion (APB)

-Number 12

-Paragraph 10

-LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.

Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 02

-Paragraph 31

-Article 5

Reference 3: http://www.xbrl.org/2003/role/presentationRef

-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 04

-Article 3

Reference 4: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 210

-SubTopic 10

-Section S99

-Paragraph 1

-Subparagraph (SX 210.5-02.31(a)(3))

-URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682

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Summary of Significant Accounting Policies (Textual) (Details) (USD $)	3 Months Ended								12 Months Ended
	Dec. 31, 2013	Sep. 30, 2013	Jun. 30, 2013	Mar. 31, 2013	Dec. 31, 2012	Sep. 30, 2012	Jun. 30, 2012	Mar. 31, 2012 operating_segment	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Accounting Policies [Line Items]
Additional Cash and Cash Equivalent Related Text									3 months
Assets Held-for-sale, Current	$ 2,179,000				$ 0				$ 2,179,000	$ 0
Investment Maturity Date									1 year
Other than Temporary Impairment Losses, Investments										753,000
Entity-Wide Revenue, Major Customer, Percentage									10.00%
Number of Operating Segments								1	1
Net income (loss)	9,813,000	9,262,000	12,605,000	9,623,000	15,538,000	2,309,000	5,519,000	7,490,000	41,303,000	30,857,000	16,550,000
Net cash provided by (used in) operating activities									22,998,000	11,892,000	490,000
Accumulated deficit	256,859,000				215,556,000				256,859,000	215,556,000
Cash and cash equivalents	22,130,000				32,003,000				22,130,000	32,003,000	25,762,000	72,396,000
Cash, Cash Equivalents and Marketable Securities [Abstract]
Recorded impairment in condensed consolidated statement of operations as sales, general and administrative expenses									0
Decrease (increase) in restricted cash									800,000	0	(45,000)
Accounts Receivable, Net
Write-off and other									0	0	0
Advertising
Advertising Expense									513,000	351,000	113,000
Intangible Assets, Net (Excluding Goodwill) [Abstract]
Asset Impairment Charges									1,571,000
Sales Revenue, Services, Net [Member] \| Exela [Member]
Concentration of Credit Risk
Customer concentration risk (percentage)									15.00%	0.00%	0.00%
Sales Revenue, Services, Net [Member] \| Shell [Member]
Concentration of Credit Risk
Customer concentration risk (percentage)									0.00%	51.00%	51.00%
Sales Revenue, Services, Net [Member] \| Merck [Member]
Concentration of Credit Risk
Customer concentration risk (percentage)									39.00%	13.00%	10.00%
Sales Revenue, Services, Net [Member] \| Novartis [Member]
Concentration of Credit Risk
Customer concentration risk (percentage)									14.00%	1.00%	1.00%
Prepaid Expenses and Other Current Assets [Member]
Accounting Policies [Line Items]
Deferred cost of sales					1,100,000					1,100,000
Core IP [Member]
Intangible Assets, Net (Excluding Goodwill) [Abstract]
Undiscounted cash flows, discount rate (percent)									19.50%	18.00%
Undiscounted cash flows, long-term growth rate (percent)									2.00%	2.00%
Fair value in excess of carrying value (percent)	44.00%								44.00%
Percentage of undiscounted cash flows per product (percent)	7.00%				38.00%				7.00%	38.00%
Percentage of undiscounted cash flows greater than the carrying value of the asset group (percent)	37.00%				14.00%				37.00%	14.00%
Customer relationships [Member]
Accounting Policies [Line Items]
Entity-Wide Revenue, Major Customer, Percentage									81.00%	83.00%
Novartis [Member]
Concentration of Credit Risk
Customer concentration risk (percentage)									50.00%	11.00%
Merck [Member]
Concentration of Credit Risk
Customer concentration risk (percentage)										53.00%
Arch [Member]
Accounts Receivable, Net
Write-off and other									387,000
Debt Securities [Member]
Cash, Cash Equivalents and Marketable Securities [Abstract]
Recorded impairment in condensed consolidated statement of operations as sales, general and administrative expenses									0
Available-for-sale Securities [Member]
Cash, Cash Equivalents and Marketable Securities [Abstract]
Realized gains (losses) from sales of marketable securities									0	0	0
Impairment of Goodwill [Member]
Intangible Assets, Net (Excluding Goodwill) [Abstract]
Asset Impairment Charges									$ 0	$ 0	$ 0
Enzyme Opportunities [Member]
Accounting Policies [Line Items]
Undiscounted cash flows, expected percentage of revenue (percent)					31.00%					31.00%
Entity-Wide Revenue, Major Customer, Percentage									10.00%
Core Pharmaceutical Business [Member]
Accounting Policies [Line Items]
Undiscounted cash flows, expected percentage of revenue (percent)					69.00%					69.00%
Entity-Wide Revenue, Major Customer, Percentage									90.00%