Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Revenues:
Product	$ 20,423	$ 35,924	$ 49,021
Collaborative research and development	6,868	49,977	70,918
Revenue sharing arrangement	4,631	150	450
Government awards	0	2,247	3,476
Total revenues	31,922	88,298	123,865
Costs and operating expenses:
Cost of product revenues	14,554	30,647	41,781
Research and development	31,606	56,785	61,049
Selling, general and administrative	26,908	31,379	36,942
Total costs and operating expenses	73,068	118,811	139,772
Loss from operations	(41,146)	(30,513)	(15,907)
Interest income	60	252	273
Interest expense and other, net	(304)	(326)	(675)
Loss before income taxes	(41,390)	(30,587)	(16,309)
Provision for (benefit from) income taxes	(87)	270	241
Net loss	$ (41,303)	$ (30,857)	$ (16,550)
Net loss per share of common stock, basic and diluted (dollars per share)	$ (1.08)	$ (0.84)	$ (0.46)
Weighted average common shares used in computing net loss per share of common stock, basic and diluted (shares)	38,231	36,768	35,674