Collaborative Research and Development Agreements (Details) (USD $)	3 Months Ended		9 Months Ended		1 Months Ended	3 Months Ended	9 Months Ended	3 Months Ended	9 Months Ended	3 Months Ended	9 Months Ended	3 Months Ended	9 Months Ended	3 Months Ended	9 Months Ended
	Sep. 30, 2013	Sep. 30, 2012	Sep. 30, 2013	Sep. 30, 2012	Nov. 30, 2007 Shell [Member]	Sep. 30, 2012 Shell [Member]	Sep. 30, 2013 Shell [Member]	Sep. 30, 2012 Merck [Member]	Sep. 30, 2013 Merck [Member]	Sep. 30, 2013 Merck [Member] Collaborative research and development [Member]	Sep. 30, 2013 Merck [Member] Collaborative research and development [Member]	Sep. 30, 2013 New Arch Enzyme Supply Agreement [Member] Arch [Member]	Sep. 30, 2013 New Arch Enzyme Supply Agreement [Member] Arch [Member]	Sep. 30, 2012 Previous Arch Agreement [Member] Arch [Member]	Sep. 30, 2012 Previous Arch Agreement [Member] Arch [Member]
Collaborative Research and Development Agreements (Textual) [Abstract]
Term of collaborative research and development agreement (years)					5 years				5 years
Amount of New Shell Agreement requires Shell pay						$ 7,500,000
Period of research agreement with shell (years)							10 years
License fee recognized as revenue										500,000	1,300,000
One year license fee paid									1,200,000
Royalties earned								500,000
Product revenue	$ 2,867,000	$ 18,569,000	$ 7,236,000	$ 49,049,000								$ 0	$ 2,100,000	$ 50,000	$ 100,000