<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>144</submissionType>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001198518</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>



        </filerInfo>
    </headerData>
    <formData>
        <issuerInfo>
            <issuerCik>0000860413</issuerCik>
            <issuerName>FIRST INTERSTATE BANCSYSTEM INC.</issuerName>
            <secFileNumber>001-34653</secFileNumber>
            <issuerAddress>
                <ns2:street1>401 North 31st Street</ns2:street1>
                <ns2:city>Billings</ns2:city>
                <ns2:stateOrCountry>MT</ns2:stateOrCountry>
                <ns2:zipCode>59101</ns2:zipCode>
            </issuerAddress>
            <issuerContactPhone>(406) 255-5311</issuerContactPhone>
            <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>BENCH RANCH LLC</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
            <relationshipsToIssuer>
                <relationshipToIssuer>Director</relationshipToIssuer>
            </relationshipsToIssuer>
        </issuerInfo>
        <securitiesInformation>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <brokerOrMarketmakerDetails>
                <name>Morgan Stanley Smith Barney LLC Executive Financial Services</name>
                <address>
                    <ns2:street1>1 New York Plaza</ns2:street1>
                    <ns2:street2>8th Floor</ns2:street2>
                    <ns2:city>New York</ns2:city>
                    <ns2:stateOrCountry>NY</ns2:stateOrCountry>
                    <ns2:zipCode>10004</ns2:zipCode>
                </address>
            </brokerOrMarketmakerDetails>
            <noOfUnitsSold>15000</noOfUnitsSold>
            <aggregateMarketValue>482169.00</aggregateMarketValue>
            <noOfUnitsOutstanding>102890614</noOfUnitsOutstanding>
            <approxSaleDate>11/11/2025</approxSaleDate>
            <securitiesExchangeName>NASDAQ</securitiesExchangeName>
        </securitiesInformation>
        <securitiesToBeSold>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <acquiredDate>12/04/2024</acquiredDate>
            <natureOfAcquisitionTransaction>Distribution from a Trust or an Estate</natureOfAcquisitionTransaction>
            <nameOfPersonfromWhomAcquired>Susan S Heyneman</nameOfPersonfromWhomAcquired>
            <isGiftTransaction>N</isGiftTransaction>
            <amountOfSecuritiesAcquired>15000</amountOfSecuritiesAcquired>
            <paymentDate>01/02/1976</paymentDate>
            <natureOfPayment>Stock Swap</natureOfPayment>
        </securitiesToBeSold>
        <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
        <securitiesSoldInPast3Months>
            <sellerDetails>
                <name>AWE' LLC</name>
                <address>
                    <ns2:street1>401 North 31st Street</ns2:street1>
                    <ns2:city>Billings</ns2:city>
                    <ns2:stateOrCountry>MT</ns2:stateOrCountry>
                    <ns2:zipCode>59101</ns2:zipCode>
                </address>
            </sellerDetails>
            <securitiesClassTitle>Common</securitiesClassTitle>
            <saleDate>11/10/2025</saleDate>
            <amountOfSecuritiesSold>20000</amountOfSecuritiesSold>
            <grossProceeds>641298.00</grossProceeds>
        </securitiesSoldInPast3Months>
        <remarks>Sales that were executed on November 11, 2025 are being reported on this Form 144 filed on November 12, 2025 given the EDGAR system was not accepting filings on November 11, 2025 in observance of the federal holiday.
 </remarks>
        <noticeSignature>
            <noticeDate>11/12/2025</noticeDate>
            <planAdoptionDates/>
            <signature>/s/ John M Heyneman Jr</signature>
        </noticeSignature>
    </formData>
</edgarSubmission>
