X0306 4 2021-09-17 1 0001863127 Tyra Biosciences, Inc. TYRA 0001881002 Alta Partners NextGen Fund II Management, LLC 115 W SNOW KING AVE, SUITE 101B JACKSON WY 83001 0 0 1 0 0001768658 Alta Partners NextGen Fund II, L.P. 115 W SNOW KING AVE, SUITE 101B JACKSON WY 83001 0 0 1 0 0001674884 Hudson Peter A C/O ALTA PARTNERS NEXTGEN FUND II MANAGE 115 W SNOW KING AVE, SUITE 101B JACKSON WY 83001 0 0 1 0 0001198325 JANNEY DANIEL C/O ALTA PARTNERS NEXTGEN FUND II MANAGE 115 W SNOW KING AVE, SUITE 101B JACKSON WY 83001 0 0 1 0 Common Stock 2021-09-17 4 C 0 3811117 A 3924046 I See footnote Common Stock 2021-09-17 4 P 0 156250 16.00 A 4080296 I See footnote Series A Preferred Stock 2021-09-17 4 C 0 1212122 0.00 D Common Stock 3148365 0 I See footnote Series B Preferred Stock 2021-09-17 4 C 0 255160 0.00 D Common Stock 662752 0 I See footnote On September 17, 2021, each share of Series A Preferred Stock and each share of Series B Preferred Stock converted into Common Stock of the Issuer at a ratio of 1-for-2.5974 without payment of further consideration upon closing of the initial public offering of the Issuer's common stock. The shares had no expiration date. As a result of the Issuer's initial public offering, the reporting persons are no longer 10% owners of the Issuer's common stock and are, therefore, no longer subject to Section 16 in connection with their transactions in the equity securities of the Issuer. These securities are held directly by Alta Partners NextGen Fund II, L.P. (the "APNG II"). The shares directly held by APNG II are indirectly held by Alta Partners NextGen Fund II Management, LLC ("APNG II Management"), which is the general partner of APNG II. The individual managing directors of APNG II Management are Robert More, Peter Hudson and Daniel Janney. The managing directors of APNG II Management exercise shared voting and investment control with respect to the shares held by APNG II. APNG II Management, Mr. Hudson and Mr. Janney disclaim beneficial ownership of all shares held by APNG II, except to the extent of its or their respective pecuniary interests therein. Mr. More is a director of the Issuer and files separate Section 16 reports. /s/ Daniel S. Janney, Manager of the Alta Partners NextGen Fund II Management, LLC, the General Partner of the Alta Partners NextGen Fund II, L.P. 2021-09-17 /s/ Daniel S. Janney, Manager of the Alta Partners NextGen Fund II Management, LLC 2021-09-17 /s/ Peter A. Hudson, individually 2021-09-17 /s/ Daniel S. Janney, individually 2021-09-17