X0306 4 2014-12-10 0 0001429560 TREVENA INC TRVN 0001399763 Alta Partners VIII, L.P. C/O ALTA PARTNERS, ONE EMBARCADERO CENTER, 37TH FLOOR SAN FRANCISCO CA 94111 0 0 1 0 0001399894 Alta Partners Management VIII, LLC C/O ALTA PARTNERS, ONE EMBARCADERO CENTER, 37TH FLOOR SAN FRANCISCO CA 94111 0 0 1 0 0001198321 CHAMPSI FARAH C/O ALTA PARTNERS, ONE EMBARCADERO CENTER, 37TH FLOOR SAN FRANCISCO CA 94111 1 0 1 0 0001198325 JANNEY DANIEL C/O ALTA PARTNERS, ONE EMBARCADERO CENTER, 37TH FLOOR SAN FRANCISCO CA 94111 0 0 1 0 0001198330 NOHRA GUY P C/O ALTA PARTNERS, ONE EMBARCADERO CENTER, 37TH FLOOR SAN FRANCISCO CA 94111 0 0 1 0 Common Stock 2014-12-10 4 P 0 500000 4.00 A 4390262 I Direct and Indirect - See Footnote These shares were purchased by Alta Partners VIII, L.P. ("APVIII"). The securities are held of record by APVIII. Alta Partners Management VIII, LLC ("APMVIII") is the general partner of APVIII. Guy Nohra, Daniel Janney and Farah Champsi are managing directors of APMVIII and exercise shared voting and investment power with respect to the shares onwed by APVIII. Each of the reporting persons disclaims beneficial ownership of such securities, except to the extent of his, her or its proportionate pecuniary interest therein. Ms. Champsi is also a director of the issuer. /s/Derek Colla, Attorney-in-Fact 2014-12-10 Derek Colla, Attorney-in-Fact 2014-12-10 Derek Colla, Attorney-in-Fact 2014-12-10 Derek Colla, Attorney-in-Fact 2014-12-10 Derek Colla, Attorney-in-Fact 2014-12-10