X0306 4 2014-02-05 0 0001429560 TREVENA INC TRVN 0001399763 Alta Partners VIII, L.P. C/O ALTA PARTNERS, ONE EMBARCADERO CENTER, 37TH FLOOR SAN FRANCISCO CA 94111 0 0 1 0 0001399894 Alta Partners Management VIII, LLC C/O ALTA PARTNERS, ONE EMBARCADERO CENTER, 37TH FLOOR SAN FRANCISCO CA 94111 0 0 1 0 0001198321 CHAMPSI FARAH C/O ALTA PARTNERS, ONE EMBARCADERO CENTER, 37TH FLOOR SAN FRANCISCO CA 94111 1 0 1 0 0001198325 JANNEY DANIEL C/O ALTA PARTNERS, ONE EMBARCADERO CENTER, 37TH FLOOR SAN FRANCISCO CA 94111 0 0 1 0 0001198330 NOHRA GUY P C/O ALTA PARTNERS, ONE EMBARCADERO CENTER, 37TH FLOOR SAN FRANCISCO CA 94111 0 0 1 0 Common Stock 2014-02-05 4 C 0 967741 0.00 A 967741 I Direct and Indirect - See Footnote Common Stock 2014-02-05 4 C 0 1354838 0.00 A 2322579 I Direct and Indirect - See Footnote Common Stock 2014-02-05 4 C 0 314516 0.00 A 2637095 I Direct and Indirect - See Footnote Common Stock 2014-02-05 4 C 0 780757 0.00 A 3417852 I Direct and Indirect - See Footnote Common Stock 2014-02-05 4 P 0 472410 7.00 A 3890262 I Direct and Indirect - See Footnote Series A Preferred Stock 2014-02-05 4 C 0 6000000 0.00 D Common Stock 967741 0 I Direct and Indirect -See footnotes Series B Preferred Stock 2014-02-05 4 C 0 8400000 0.00 D Common Stock 1354838 0 I Direct and Indirect - See footnotes Series B-1 Preferred Stock 2014-02-05 4 C 0 1950000 0.00 D Common Stock 314516 0 I Direct and Indirect - See footnotes Series C Preferred Stock 2014-02-05 4 C 0 4840686 0.00 D Common Stock 780757 0 I Direct and Indirect - See footnotes Each share of convertible preferred stock was convertible at any time, at the holder's election, into the issuer's common stock on a 6.2 to 1 basis. Effective immediately prior to the closing of the issuer's initial public offering of its common stock, each share of convertible preferred stock automatically converted on a 6.2 to 1 basis into shares of common stock of the issuer. The convertible preferred stock had no expiration date. The securities are held of record by Alta Partners VIII, L.P. ("APVIII"). Alta Partners Management VIII, LLC ("APMVIII") is the general partner of APVIII. Guy Nohra, Daniel Janney and Farah Champsi are managing directors of APMVIII and exercise shared voting and investment power with respect to the shares onwed by APVIII. Each of the reporting persons disclaims beneficial ownership of such securities, except to the extent of his, her or its proportionate pecuniary interest therein. Ms. Champsi is also a director of the issuer. Includes two shares of common stock issued to the reporting persons in connection with the aggregation of fractional shares. These shares were purchased by APVIII. /s/Derek Colla, Attorney-in-Fact 2014-02-07 Derek Colla, Attorney-in-Fact 2014-02-07 Derek Colla, Attorney-in-Fact 2014-02-07 Derek Colla, Attorney-in-Fact 2014-02-07 Derek Colla, Attorney-in-Fact 2014-02-07