X0303 4 2009-10-05 1 0001183765 THRESHOLD PHARMACEUTICALS INC THLD 0001257444 ALTA BIOPHARMA PARTNERS III LP ONE EMBARCADERO CENTER, SUITE 3700 SAN FRANCISCO CA 94111 0 0 0 1 Former 10% owner 0001280265 ALTA BIOPHARMA PARTNERS III GMBH & CO BETEILIGUNGS KG ONE EMBARCADERO CENTER, SUITE 3700 SAN FRANCISCO CA 94111 0 0 0 1 Former 10% owner 0001280234 ALTA BIOPHARMA MANAGEMENT III LLC ONE EMBARCADERO CENTER, SUITE 3700 SAN FRANCISCO CA 94111 0 0 0 1 Former 10% owner 0001280238 ALTA EMBARCADERO BIOPHARMA PARTNERS III LLC ONE EMBARCADERO CENTER, SUITE 3700 SAN FRANCISCO CA 94111 0 0 0 1 Former 10% owner 0001198323 DELEAGE JEAN ONE EMBARCADERO CENTER SUITE 3700 SAN FRANCISCO CA 94111 0 0 0 1 Former 10% owner 0001198321 CHAMPSI FARAH ONE EMBARCADERO CENTER SUITE 3700 SAN FRANCISCO CA 94132 0 0 0 1 Former 10% owner 0001198332 PENHOET EDWARD ONE EMBARCADERO CENTER SUITE 3700 SAN FRANCISCO CA 94111 0 0 0 1 Former 10% owner 0001211840 HURWITZ EDWARD ONE EMBARCADERO CENTER, SUITE 3700 SAN FRANCISCO CA 94111 0 0 0 1 Former 10% owner Common Stock 2009-10-05 4 P 0 239768 1.91 A 1439921 D Common Stock 2009-10-05 4 P 0 16103 1.91 A 96704 I See footnotes Common Stock 2009-10-05 4 P 0 5909 1.91 A 35485 I See footnotes Warrant 2.23 2009-10-05 4 P 0 95907 0.00 A 2014-10-05 Common Stock 95907 499987 D Warrant 2.23 2009-10-05 4 P 0 6441 0.00 A 2014-10-05 Common Stock 6441 33578 I See footnotes Warrant 2.23 2009-10-05 4 P 0 2363 0.00 A 2014-10-05 Common Stock 2363 12321 I See footnotes These securities are held of record by Alta BioPharma Partners III, L.P.("ABPIII"). Alta BioPharma Management III, LLC ("ABMIII") is the General Partner of ABPIII and Managing Limited Partner of Alta BioPharma Partners III GmbH & Co. Beteiligungs KG ("ABPIIIKG"). Jean Deleage, Farah Champsi, Edward Penhoet, and Edward Hurwitz are directors of ABMIII and managers of Alta Embarcadero BioPharma Partners III, LLC ("AEBPIII" and, along with ABPIII and ABPIIIKG, the "Funds") and they exercise shared voting and investment power with respect to the shares owned by the Funds. Each reporting persons disclaims beneficial ownership of such securities, except to the extend of his or her pecuniary interest therein. These securities are held of record by ABPIIIKG. These securities are held of record by AEBPIII. These warrants are immediately exercisable. These warrants were issued pursuant to Securities Purchase Agreement ("SPA") dated September 29, 2009. For every share of stock purchased at $1.91 according to the SPA, 0.4 share of warrant was issued. By Alta BioPharma Management III, LLC, /s/ Jean Deleage, Director 2009-10-06 Alta BioPharma Management III, LLC, It's General Partner, /s/ Jean Deleage, Director 2009-10-06 /s/ Jean Deleage, Director 2009-10-06 /s/ Jean Deleage, Manager 2009-10-06 /s/ Jean Deleage 2009-10-06 /s/ Farah Champsi 2009-10-06 /s/ Edward Penhoet 2009-10-06 /s/ Edward Hurwitz 2009-10-06