X0202 4 2005-08-08 1 0001118361 RENOVIS INC RNVS 0001276361 ALTA PARTNERS II INC ONE EMBARCADERO CENTER SUITE 4050 SAN FRANCISCO CA 94111 0 0 0 1 No longer 10% Owner 0001163156 ALTA BIOPHARMA PARTNERS II LP ONE EMBARCADERO CENTER SUITE 4050 SAN FRANCISCO CA 94111 0 0 0 1 No longer 10% Owner 0001163189 ALTA BIOPHARMA MANAGEMENT II LLC ONE EMBARCADERO CENTER SUITE 4050 SAN FRANCISCO CA 94111 0 0 0 1 No longer 10% Owner 0001163157 ALTA EMBARCADERO BIOPHARMA PARTNERS II LLC ONE EMBARCADERO CENTER SUITE 4050 SAN FRANCISCO CA 94111 0 0 0 1 No longer 10% Owner 0001198323 DELEAGE JEAN ONE EMBARCADERO CENTER SUITE 4050 SAN FRANCISCO CA 94111 0 0 0 1 No longer 10% Owner 0001198328 MARDUEL ALIX ONE EMBARCADERO CENTER SUITE 4050 SAN FRANCISCO CA 94111 0 0 0 1 No longer 10% Owner 0001198321 CHAMPSI FARAH ONE EMBARCADERO CENTER SUITE 4050 SAN FRANCISCO CA 94111 0 0 0 1 No longer 10% Owner Common Stock 2005-08-08 4 J 0 482259 0.00 D 665976 I See footnote Common Stock 2005-08-08 4 J 0 17741 0.00 D 24499 I See footnote n/a Alta BioPharma Partners II, L.P. ("ABPII") distributed 482,259 shares to its general & limited partners based on their respective capital interests in ABPII in accordance with the Partnership Agreement without receipt of additional consideration from such partners. Alta Partners II, Inc. ("APII") provides investment advisory services to several venture capital funds including, Alta BioPharma Partners II, L.P. ("ABPII") & Alta Embarcadero BioPharma Partners II, LLC ("AEP"). As a result of the Stock Distribution on 8/8/2005, ABPII now beneficially owns 665,976 shares and AEPII now owns 24,499 shares. The respective general partners and managing members of ABPII and AEBPII exercise sole voting and investment power with respect to the shares owned by such funds. Certain principals of APII are managing directors of Alta BioPharma Managment II, LLC (which is the general partner of ABPII) & managers of AEBPII (respectively) As managing directors and managers of such funds, they may be deemed to share voting and investment powers for the shares held by the foregoing funds. The principals of APII disclaim benefical ownership of all such shares held by the foregoing funds, except to the extent of their proportionate pecuniary interests therein. Alta Embarcadero BioPharma Partners II, LLC ("AEPII") distributed 17,741 shares to its members based on their respective captial interests in AEPII in accordance with the Operating Agreement without receipt of additional consideration from such partners. Cross-Reference with the Form 4 filed for Alta Partners filed on 8/9/2005 Jean Deleage, President 2005-08-09 Farah Champsi, Managing Director 2005-08-09 Farah Champsi, Managing Director 2005-08-09 Farah Champsi, Manager 2005-08-09 Jean Deleage 2005-08-09 Alix Marduel 2005-08-09 Farah Champsi 2005-08-09