<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2004-10-15</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001138812</issuerCik>
        <issuerName>COTHERIX INC</issuerName>
        <issuerTradingSymbol>CTRX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001276361</rptOwnerCik>
            <rptOwnerName>ALTA PARTNERS II INC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE EMBARCADERO CENTER, SUITE 4050</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94111</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001106287</rptOwnerCik>
            <rptOwnerName>GRUENER GARRETT</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE EMBARCADERO CENTER, SUITE 4050</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94111</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001198321</rptOwnerCik>
            <rptOwnerName>CHAMPSI FARAH</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE EMBARCADERO CENTER, SUITE 4050</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94111</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001198323</rptOwnerCik>
            <rptOwnerName>DELEAGE JEAN</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE EMBARCADERO CENTER, SUITE 4050</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94111</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001198330</rptOwnerCik>
            <rptOwnerName>NOHRA GUY P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE EMBARCADERO CENTER, SUITE 4050</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94111</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001198328</rptOwnerCik>
            <rptOwnerName>MARDUEL ALIX</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>ONE EMBARCADERO CENTER, SUITE 4050</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94111</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>142291</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnotes</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Director Stock Option</value>
                <footnoteId id="F4"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.5446</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F5"/>
            </exerciseDate>
            <expirationDate>
                <value>2014-01-05</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>24240</value>
                    <footnoteId id="F4"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Director Stock Option</value>
                <footnoteId id="F6"/>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>2.1782</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F5"/>
            </exerciseDate>
            <expirationDate>
                <value>2014-02-11</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>15150</value>
                    <footnoteId id="F6"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F6"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Series B Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F8"/>
                <footnoteId id="F9"/>
                <footnoteId id="F10"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F5"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F7"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>715481</value>
                    <footnoteId id="F8"/>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Series C Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F9"/>
                <footnoteId id="F10"/>
                <footnoteId id="F11"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F5"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F7"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1147065</value>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
                    <footnoteId id="F11"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Series C Preferred Stock</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F9"/>
                <footnoteId id="F10"/>
                <footnoteId id="F12"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F5"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F7"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1363200</value>
                    <footnoteId id="F9"/>
                    <footnoteId id="F10"/>
                    <footnoteId id="F12"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See footnote</value>
                    <footnoteId id="F2"/>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Common Stock: Alta California Partners III, L.P. (&quot;ACPIII&quot;) beneficially owns 137,643 shares and Alta Embarcadero Partners III, LLC (&quot;AEPIII&quot;) beneficially owns 4,648 shares.</footnote>
        <footnote id="F2">Daniel Janney, Director, is a managing director of Alta California Management Partners III, LLC (&quot;ACMPIII&quot;) (which is the general partner (&quot;gp&quot;) of Alta California Partners III, L.P. (&quot;ACPIII&quot;), &amp; a manager of Alta Embarcadero Partners III, LLC (&quot;AEPIII&quot;). As a managing director &amp; manager of such funds, he may be deemed to share voting &amp; investment powers over the shares held by ACPIII and AEPIII. He is a member of Alta BioPharma Management III, LLC (&quot;ABMPIII&quot;) (which is the gp of Alta BioPharma Parnters III, L.P. (&quot;ABPIII&quot;). He disclaims beneficial ownership of all such shares held by the foregoing funds except to the extent of his proportionate pecuniary interest therein.</footnote>
        <footnote id="F3">Alta Partners II, Inc. (&quot;APII&quot;) provides investment advisory services to several funds incl. ACPIII, AEPIII, ABPIII, ABPIIIKG &amp; AEBPIII. The respective managing directors (&quot;md&quot;) of ABMPIII (the gp of ABPIII and ABPIIIKG) &amp; managers of AEPIII exercise sole voting &amp; investment power with respect to the shares owned by such funds. Garrett Gruener, Guy Nohra &amp; Daniel Janney (collectively the &quot;principals&quot;) are md of ACMPIII &amp; managers of AEPIII thus they may be deemed to share voting &amp; investment powers over the shares held by the funds. Jean Deleage, Alix Marduel, Farah Champsi, Edward Hurwitz &amp; Edward Penhoet (collectively the &quot;principals&quot;) are directors of ABPMPIII (the gp of ABPIII and ABPIIIKG) &amp; managers of AEBPIII thus they may be deemed to share voting &amp; investment powers over the shares held by the funds. The principals of APII disclaim beneficial ownership of all such shares held by the foregoing funds except to the extent of their proportionate pecuniary interests therein.</footnote>
        <footnote id="F4">Daniel Janney holds Stock Options to purchase 24,240 shares of Common Stock: options granted on 1/6/04 for 18,180 shares which will vest at 1/12th of the option sh upon the optionee's completion of each of the next consecutive 3-month periods of continuous service starting 1/6/04, and the 2nd set of options for 6,060 shares granted on 1/6/04 will vest at 1/4th of the option sh upon the optionee's completion of each of the next consecutive 3-month periods of continuous service starting 1/6/04.</footnote>
        <footnote id="F5">Immediately.</footnote>
        <footnote id="F6">Daniel Janney holds Stock Options to purchase 15,150 sh Common Stock granted on 2/12/04 that will vest at 1/12th of the option share upon the optionee's completion of each of the next consecutive 3-month periods of continuous service starting 2/12/04.</footnote>
        <footnote id="F7">Not Applicable</footnote>
        <footnote id="F8">Series B Preferred Stock: ACPIII beneficially owns 695,371 shares and AEPIII beneficially owns 20,110 shares.</footnote>
        <footnote id="F9">Reflects 1:0.606 reverse stock split</footnote>
        <footnote id="F10">Reflects the conversion adjustment of 1.0626 for Series B Preferred Stock, and the conversion adjustment of 1.0686 for the Series C Preferred Stock.</footnote>
        <footnote id="F11">Series C Preferred Stock: ACPIII beneficially owns 1,109,597 shares and AEPIII beneficially owns 37,468 shares.</footnote>
        <footnote id="F12">Series C Preferred Stock: Alta BioPharma Partners III, L.P. (&quot;ABPIII&quot;) beneficially owns 1,248,583 shares, Alta BioPharma Partners III GmbH &amp; Co. Beteiligungs KG (&quot;ABPIIIKG&quot;) beneficially owns 83,851shares and Alta Embarcadero BioPharma Partners III, LLC (&quot;AEBPIII&quot;) beneficially owns 30,766 shares.</footnote>
    </footnotes>

    <remarks>Please cross-reference this Form 3 with the Form 4 filed on October 15, 2004 for Daniel Janney.</remarks>

    <ownerSignature>
        <signatureName>Jean Deleage, President APII</signatureName>
        <signatureDate>2004-10-15</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Garrett Gruener</signatureName>
        <signatureDate>2004-10-15</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Farah Champsi</signatureName>
        <signatureDate>2004-10-15</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Jean Deleage</signatureName>
        <signatureDate>2004-10-15</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Guy Nohra</signatureName>
        <signatureDate>2004-10-15</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Alix Marduel</signatureName>
        <signatureDate>2004-10-15</signatureDate>
    </ownerSignature>
</ownershipDocument>

