<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0303</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2010-07-30</periodOfReport>

    <issuer>
        <issuerCik>0001278021</issuerCik>
        <issuerName>MARKETAXESS HOLDINGS INC</issuerName>
        <issuerTradingSymbol>MKTX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001343722</rptOwnerCik>
            <rptOwnerName>Trudeau Robert</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TECHNOLOGY CROSSOVER VENTURES</rptOwnerStreet1>
            <rptOwnerStreet2>528 RAMONA STREET</rptOwnerStreet2>
            <rptOwnerCity>PALO ALTO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94301</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>May be part of a 13(d) group</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001082906</rptOwnerCik>
            <rptOwnerName>HOAG JAY C</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TECHNOLOGY CROSSOVER VENTURES</rptOwnerStreet1>
            <rptOwnerStreet2>528 RAMONA STREET</rptOwnerStreet2>
            <rptOwnerCity>PALO ALTO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94301</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>May be part of a 13(d) group</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001197937</rptOwnerCik>
            <rptOwnerName>KIMBALL RICK</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TECHNOLOGY CROSSOVER VENTURES</rptOwnerStreet1>
            <rptOwnerStreet2>528 RAMONA STREET</rptOwnerStreet2>
            <rptOwnerCity>PALO ALTO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94301</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>May be part of a 13(d) group</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001188456</rptOwnerCik>
            <rptOwnerName>DREW JOHN</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TECHNOLOGY CROSSOVER VENTURES</rptOwnerStreet1>
            <rptOwnerStreet2>528 RAMONA STREET</rptOwnerStreet2>
            <rptOwnerCity>PALO ALTO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94301</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>May be part of a 13(d) group</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001188444</rptOwnerCik>
            <rptOwnerName>REYNOLDS JON Q JR</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TECHNOLOGY CROSSOVER VENTURES</rptOwnerStreet1>
            <rptOwnerStreet2>528 RAMONA STREET</rptOwnerStreet2>
            <rptOwnerCity>PALO ALTO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94301</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>May be part of a 13(d) group</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001188458</rptOwnerCik>
            <rptOwnerName>GRIFFITH WILLIAM</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TECHNOLOGY CROSSOVER VENTURES</rptOwnerStreet1>
            <rptOwnerStreet2>528 RAMONA STREET</rptOwnerStreet2>
            <rptOwnerCity>PALO ALTO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94301</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>1</isOther>
            <otherText>May be part of a 13(d) group</otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2010-07-30</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>4923</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>4923</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Robert W. Trudeau</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>8403</value>
                    <footnoteId id="F4"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>TCV VI Management, L.L.C.</value>
                    <footnoteId id="F5"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Represents a grant of restricted stock pursuant to the issuer's 2004 Incentive Plan (as amended and restated effective April 28, 2006).</footnote>
        <footnote id="F2">Excludes 4,178 shares that were previously held by Robert W. Trudeau (&quot;Trudeau&quot;), but were transferred from Trudeau to TCV VI Management, L.L.C. (&quot;TCM VI&quot;) on June 7, 2010, and are now held directly by TCM VI.</footnote>
        <footnote id="F3">These shares of restricted stock are directly held by Trudeau. Trudeau has sole voting and dispositive power over the shares; however, TCM VI owns 100% of the pecuniary interest therein. Trudeau, Jay C. Hoag, Richard H. Kimball, John L. Drew, Jon Q. Reynolds, Jr. and William J.G. Griffith IV (collectively, the &quot;TCM Members&quot;) are members of TCM VI, but disclaim beneficial ownership of such shares except to the extent of their pecuniary interest therein.</footnote>
        <footnote id="F4">Excludes 4,923 shares directly held of record by Trudeau, but includes 4,178 shares that were previously held directly by Trudeau, but were transferred from Trudeau to TCM VI on June 7, 2010, and are now held directly by TCM VI.</footnote>
        <footnote id="F5">These shares are directly held by TCM VI.  The TCM Members are members of TCM VI, but disclaim beneficial ownership of such shares except to the extent of their pecuniary interest therein.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Frederic D. Fenton  Authorized signatory for Robert W. Trudeau</signatureName>
        <signatureDate>2010-08-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Frederic D. Fenton  Authorized signatory for Jay C. Hoag</signatureName>
        <signatureDate>2010-08-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Frederic D. Fenton  Authorized signatory for Richard H. Kimball</signatureName>
        <signatureDate>2010-08-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Frederic D. Fenton  Authorized signatory for John L. Drew</signatureName>
        <signatureDate>2010-08-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Frederic D. Fenton  Authorized signatory for Jon Q. Reynolds Jr.</signatureName>
        <signatureDate>2010-08-03</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>Frederic D. Fenton  Authorized signatory for William J.G. Griffith IV</signatureName>
        <signatureDate>2010-08-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
