X0202 4 2008-05-13 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001197034 BRIMBLECOMBE ROGER W C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY STREET CAMBRIDGE MA 02139 1 0 0 0 Common Stock 2008-05-13 4 M 0 3334 14.20 A 3334 D Common Stock 2008-05-13 4 S 0 700 27.00 D 2634 D Common Stock 2008-05-13 4 S 0 300 27.03 D 2334 D Common Stock 2008-05-13 4 S 0 300 27.07 D 2034 D Common Stock 2008-05-13 4 S 0 300 27.08 D 1734 D Common Stock 2008-05-13 4 S 0 200 27.13 D 1534 D Common Stock 2008-05-13 4 S 0 100 27.14 D 1434 D Common Stock 2008-05-13 4 S 0 500 27.19 D 934 D Common Stock 2008-05-13 4 S 0 300 27.27 D 634 D Common Stock 2008-05-13 4 S 0 300 27.46 D 334 D Common Stock 2008-05-13 4 S 0 334 27.70 D 0 D Stock Option 14.20 2008-05-13 4 A 0 3334 0 D 1998-09-01 2008-05-31 Common Stock 3334 6666 D Transaction made pursuant to Dr. Brimblecombe's company approved trading plan established under Rule 10b5-1. Right to buy under 1996 Stock and Option Plan, fully vested on grant date, 6/1/1998. Valerie L. Andrews, Attorney-In-Fact 2008-05-15