X0201 42003-10-21 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001197023 BOGER JOSHUA S C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY STREET CAMBRIDGE MA 02139 1100Chairman & CEOCommon Stock2003-10-214M0200007.88A880977DCommon Stock2003-10-214S02000013.40D860977DCommon Stock217022I9,522 shares 401(k); 207,500 shares in trustStock Option7.882003-10-214M0200000D1994-03-312003-11-30Common Stock200001643223DTransaction made pursuant to Dr. Boger's company approved trading plan established under Rule 10b5-1.Shares held in trust for Dr. Boger's children. Dr. Boger disclaims beneficial ownership of such shares. Right to buy under 1991 Stock and Option Plan, vesting in 20 equal quarterly installments from 12/01/1993.Valerie L. Andrews, Attorney-In-Fact2003-10-22