X0201 4 2004-03-10 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001197020 SATO VICKI L C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY STREET CAMBRIDGE MA 02139 0 1 0 0 President Common Stock 2004-03-10 4 M 0 3800 6.00 A 104408 D Common Stock 2004-03-10 4 S 0 3800 10.70 D 100608 D Common Stock 7125 I 401(k) Stock Option 6.00 2004-03-10 4 M 0 3800 0 D 1995-03-08 2004-12-07 Common Stock 3800 1190409 D Transaction made pursuant to Dr. Sato's company approved trading plan established under Rule 10b5-1. Right to buy under 1994 Stock and Option Plan, vesting quarterly over 5 years from 12/8/1994. Kenneth S. Boger, Attorney-In-Fact 2004-03-11