X0303 4 2008-09-03 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001197014 ALAM JOHN J C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY STREET CAMBRIDGE MA 01239 0 1 0 0 EVP, Med. Dev. Group & CMO Common Stock 2008-09-03 4 M 0 6612 10.19 A 143404 D Common Stock 2008-09-03 4 S 0 6612 25.86 D 136792 D Common Stock 5140 I 401(k) Stock Option 10.19 2008-09-03 4 M 0 6612 0 D 2008-09-16 Common Stock 6612 6614 D Transaction for sales of common stock made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1. Open market sales reported on this line occurred at a weighted average price of $25.86 (range $25.49 to $26.26). Dr. Alam undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. Fully vested. Valerie L. Andrews, Attorney-In-Fact 2008-09-04