X0202 4 2007-12-11 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001197014 ALAM JOHN J C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY STREET CAMBRIDGE MA 01239 0 1 0 0 EVP, Medicines Dev. & CMO Common Stock 2007-12-11 4 S 0 50 25.41 D 119274 D Common Stock 2007-12-11 4 S 0 50 25.52 D 119224 D Common Stock 2007-12-11 4 S 0 50 25.57 D 119174 D Common Stock 2007-12-11 4 S 0 50 25.58 D 119124 D Common Stock 2007-12-11 4 S 0 140 25.59 D 118984 D Common Stock 2007-12-11 4 S 0 45 25.60 D 118939 D Common Stock 2007-12-11 4 S 0 50 25.82 D 118889 D Common Stock 2007-12-11 4 S 0 45 25.96 D 118844 D Common Stock 5075 I 401(k) Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1. Valerie L. Andrews, Attorney-In-Fact 2007-12-12