X0202 4 2007-05-07 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001197014 ALAM JOHN J C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY STREET CAMBRIDGE MA 01239 0 1 0 0 EVP, Medicines Dev. & CMO Common Stock 2007-05-07 4 S 0 32500 30.59 D 102960 D Common Stock 2007-05-07 4 M 0 5550 10.19 A 108510 D Common Stock 2007-05-07 4 M 0 3188 13.63 A 111698 D Common Stock 2007-05-07 4 M 0 7626 13.11 A 119324 D Common Stock 6265 I 401(k) Stock Option 10.19 2007-05-07 4 M 0 5550 0 D 1998-12-17 2008-09-16 Common Stock 5550 0 D Stock Option 13.63 2007-05-07 4 M 0 3188 0 D 1999-03-10 2008-12-09 Common Stock 3188 0 D Stock Option 13.11 2007-05-07 4 M 0 7626 0 D 2000-03-02 2009-12-01 Common Stock 7626 0 D Transaction made pursuant to Dr. Alam's company approved trading plan established under Rule 10b5-1. Right to buy under 1996 Stock and Option Plan. Fully Vested Kenneth S. Boger, Attorney-In-Fact 2007-05-08