X0202 4 2007-01-31 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001197014 ALAM JOHN J C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY STREET CAMBRIDGE MA 01239 0 1 0 0 EVP, Medicines Dev., & CMO Common Stock 2007-01-31 4 M 0 1000 18.47 A 136460 D Common Stock 2007-01-31 4 M 0 500 9.07 A 136960 D Common Stock 2007-01-31 4 S 0 1000 35.46 D 135960 D Common Stock 2007-01-31 4 S 0 500 35.46 D 135460 D Common Stock 6265 I 401(k) Stock Options 18.47 2007-01-31 4 M 0 1000 0 D 2007-09-25 Common Stock 1000 1966 D Stock Options 9.07 2007-01-31 4 M 0 500 0 D 2004-03-11 2013-12-10 Common Stock 500 9400 D Transaction made pursuant to Dr. Alam's company approved trading plan established under rule 10b5-1. Fully exercisable. Right to buy under 1996 Stock and Option Plan, vesting quarterly over 4 years from 12/11/2003. Valerie L. Andrews, Attorney-In-Fact 2007-02-01