144 0001193210 XXXXXXXX LIVE 0001232524 Jazz Pharmaceuticals Plc 001-33500 5th Floor Waterloo Exchange Waterloo Road Dublin L2 D04 E5W7 353-1-634-7800 Bruce C Cozadd Officer Common Merrill Lynch

3075B Hansen Way 1st Floor Palo Alto CA 94304

18000 3259537.42 60765116 11/18/2025 Nasdaq Common 03/02/2017 Stock Option Exercise Jazz Pharmaceuticals Plc N 4362 03/02/2017 Cash Common 03/05/2022 Stock Option Exercise Jazz Pharmaceuticals Plc N 13638 03/05/2022 Cash N Bruce Cozadd

5th Floor Waterloo Exchange Waterloo Road Dublin L2 D04-E5W7

Common 10/03/2025 3500 490000 Bruce Cozadd

5th Floor Waterloo Exchange Waterloo Road Dublin L2 D04-E5W7

Common 10/01/2025 2000 263560 Bruce Cozadd

5th Floor Waterloo Exchange Waterloo Road Dublin L2 D04-E5W7

Common 09/02/2025 6000 771690 11/18/2025 Bruce C Cozadd