<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001193210</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001232524</issuerCik>
      <issuerName>Jazz Pharmaceuticals Plc</issuerName>
      <secFileNumber>001-33500</secFileNumber>
      <issuerAddress>
        <com:street1>5th Floor Waterloo Exchange</com:street1>
        <com:street2>Waterloo Road</com:street2>
        <com:city>Dublin</com:city>
        <com:stateOrCountry>L2</com:stateOrCountry>
        <com:zipCode>D04 E5W7</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>353-1-634-7800</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Bruce C Cozadd</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>3075B Hansen Way 1st Floor</com:street1>
          <com:city>Palo Alto</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94304</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>3500</noOfUnitsSold>
      <aggregateMarketValue>490000</aggregateMarketValue>
      <noOfUnitsOutstanding>60658809</noOfUnitsOutstanding>
      <approxSaleDate>10/03/2025</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>10/04/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Executive Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Jazz Pharmaceuticals Plc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>839</amountOfSecuritiesAcquired>
      <paymentDate>10/04/2021</paymentDate>
      <natureOfPayment>n/a</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>11/01/2021</acquiredDate>
      <natureOfAcquisitionTransaction>Executive Compensation</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Jazz Pharmaceuticals Plc</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2661</amountOfSecuritiesAcquired>
      <paymentDate>11/01/2021</paymentDate>
      <natureOfPayment>n/a</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bruce C Cozadd</name>
        <address>
          <com:street1>5th Floor Waterloo Exchange</com:street1>
          <com:street2>Waterloo Road</com:street2>
          <com:city>Dublin 4</com:city>
          <com:stateOrCountry>L2</com:stateOrCountry>
          <com:zipCode>D04-E5W7</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>10/01/2025</saleDate>
      <amountOfSecuritiesSold>2000</amountOfSecuritiesSold>
      <grossProceeds>263560</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bruce C Cozadd</name>
        <address>
          <com:street1>5th Floor Waterloo Exchange</com:street1>
          <com:street2>Waterloo Road</com:street2>
          <com:city>Dublin 4</com:city>
          <com:stateOrCountry>L2</com:stateOrCountry>
          <com:zipCode>D04-E5W7</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>09/02/2025</saleDate>
      <amountOfSecuritiesSold>6000</amountOfSecuritiesSold>
      <grossProceeds>771690</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Bruce C Cozadd</name>
        <address>
          <com:street1>5th Floor Waterloo Exchange</com:street1>
          <com:street2>Waterloo Road</com:street2>
          <com:city>Dublin 4</com:city>
          <com:stateOrCountry>L2</com:stateOrCountry>
          <com:zipCode>D04-E5W7</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <saleDate>08/01/2025</saleDate>
      <amountOfSecuritiesSold>1000</amountOfSecuritiesSold>
      <grossProceeds>113210</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>10/03/2025</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>06/05/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>Bruce C Cozadd</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
