X0306 4 2017-10-02 0000820081 CAMBREX CORP CBM 0001192621 KLOSK STEVEN M ONE MEADOWLANDS PLAZA EAST RUTHERFORD NJ 07073 1 1 President & CEO Common Stock 2017-10-02 4 M 0 4000 5.72 A 87328 D Common Stock 2017-10-02 4 S 0 4000 54.9576 D 83328 D Stock Option (right to buy) 5.72 2017-10-02 4 M 0 4000 0 A 2018-10-18 Common Stock 4000 0 D The exercise of stock options and sale of corresponding shares reported herein was carried out pursuant to a plan adopted in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $54.70 to $55.25 inclusive. The reporting person undertakes to provide to Cambrex Corporation, any security holder of Cambrex Corporation, or staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this Footnote 2 to this Form 4. The option representing a right to purchase 100,000 shares became exercisable in four equal installments beginning October 18, 2012, which was the first anniversary of the date on which the option was granted. /s/ Danielle Mann for Steven Klosk by POA 2017-10-03