CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' DEFICIT - USD ($) $ in Thousands	Common Stock	Additional Paid-in-Capital	Accumulated Other Comprehensive Income	Accumulated Deficit	Treasury Stock	Noncontrolling Interest	Total
Balance at Dec. 31, 2012	$ 5	$ 4,555		$ (134,607)		$ (6,157)	$ (136,204)
Balance (in shares) at Dec. 31, 2012	2,004,000
Stockholders' Deficit
Common stock issued under stock plans		172				1	173
Common stock issued under stock plans (in shares)	118,000
Share-based compensation		1,346					1,346
Other comprehensive income			$ 2				2
Net loss				(12,639)		(1,588)	(14,227)
Purchase of treasury stock					$ (132)		$ (132)
Purchase of treasury stock (in shares)					(28,000)		(28,000)
Balance at Dec. 31, 2013	$ 5	6,073	2	(147,246)	$ (132)	(7,744)	$ (149,042)
Balance (in shares) at Dec. 31, 2013	2,122,000				(28,000)
Stockholders' Deficit
Common stock issued under stock plans	$ 1	552				70	623
Common stock issued under stock plans (in shares)	348,000
Share-based compensation		1,530					1,530
Other comprehensive income			42				42
Net loss				(12,126)		(1,931)	(14,057)
Balance at Dec. 31, 2014	$ 6	8,155	44	(159,372)	$ (132)	(9,605)	$ (160,904)
Balance (in shares) at Dec. 31, 2014	2,470,000				(28,000)		2,442,000
Stockholders' Deficit
Conversion of preferred stock into common stock	$ 17	159,060					$ 159,077
Stock Issued During Period, Shares, Conversion of Convertible Securities	21,736,000						21,736,367
Issuance of common stock in initial public offering	$ 7	113,582					$ 113,589
Issuance of common stock in initial public offering (in shares)	6,900,000
Common stock issued under stock plans	$ 2	2,979					2,981
Common stock issued under stock plans (in shares)	1,097,000
Exercise of common stock warrant		188					188
Exercise of common stock warrant (in shares)	6,000
Share-based compensation		7,889					7,889
Other comprehensive income			7				7
Net loss				(37,241)		(1,080)	(38,321)
Deconsolidation of DOSE						$ 10,685	10,685
Balance at Dec. 31, 2015	$ 32	$ 291,853	$ 51	$ (196,613)	$ (132)		$ 95,191
Balance (in shares) at Dec. 31, 2015	32,209,000				(28,000)		32,181,000