X0306 4 2022-06-08 0 0001850838 Omega Therapeutics, Inc. OMGA 0001192128 BESHAR LUKE M C/O OMEGA THERAPEUTICS, INC. 20 ACORN PARK DRIVE CAMBRIDGE MA 02140 1 0 0 0 Option (Right to Buy) 3.31 2022-06-08 4 A 0 18118 0.00 A 2032-06-07 Common Stock 18118 18118 D The options vest and become exercisable on the earlier of (i) the date of the Issuer's next annual meeting of stockholders and (ii) the first anniversary of the date of grant, subject to the Reporting Person's continued service on the Issuer's Board of Directors through such vesting date. /s/ Barbara Chan as Attorney-in-Fact for Luke M. Beshar 2022-06-10