X0202 4 2007-11-26 0 0001303497 CardioVascular BioTherapeutics, Inc. cvbt 0001192021 HORN SETH A 1635 VILLAGE CENTER CIRCLE, SUITE 250 LAS VEGAS NV 89134 0 1 0 0 Corporate Controller & VP ISO (Right to Buy) 1 2007-11-26 4 A 0 82500 1 A 2007-11-26 2017-11-26 Common Stock 82500 102500 D The option grant was executed on 12/21/07 by the Reporting Person. Option grant pursuant to 2004 Stock Option Plan registered on Form S-8 recommended by the CEO and approved by the Board of Directors on November 26, 2007 and thus such transaction, and purchased pursuant to exercise of this option, are exempt from Section 16b pursuant to Rule 16b-3(d)(1). The option grant vests one-third immediately and the remainder ratably monthly over a two-year period commencing 11/26/07 and shall be fully vested on 11/26/09. /s/Vincent J. Roth, Attorney-in-Fact for Seth Horn 2007-11-27