X0202 4 2005-08-02 0 0001303497 CardioVascular BioTherapeutics, Inc. cvbt 0001192021 HORN SETH A 1635 VILLAGE CENTER CIRCLE SUITE 250 LAS VEGAS NV 89134 0 0 0 1 Corporate Controller Common Stock 2005-08-02 4 P 0 1000 6.35 A 3000 D Common Stock 2006-05-22 4 A 0 1 0 A 5001 D The amount of shares purchased on this date have previously been reported and included in the total direct beneficial holdings as reflected in Table 1 Column 5 of the Form 4 filed on 10/6/2005. Commemorative certificate representing one share of common stock awarded for services provided in connection with the Issuer's IPO and approved by the Board of Directors on May 22,2006, thus transaction is exempt pursuant to Rule 16b-3(d)(1). /s/Vincent J. Roth, Attorney-in-Fact for Seth A. Horn 2006-05-24