X0202 4 2005-08-16 0 0001303497 CardioVascular BioTherapeutics, Inc. CVBT 0001192021 HORN SETH A 1700 WEST HORIZON RIDGE PARKWAY SUITE 100 HENDERSON NV 89012 0 0 0 1 Controller Incentive Stock Option (Right to Buy) 10 2005-08-16 4 A 0 15000 10 A 2008-11-20 2015-08-16 Common Stock 15000 15000 D Incentive Stock Option (Right to Buy) 10 2005-08-17 4 A 0 5000 10 A 2005-08-17 2015-08-17 Common Stock 5000 20000 D Option grant pursuant to stock plan registered on Form S-8 and approved by the Board of Directors and thus such transaction and purchases pursuant to exercises of this option are exempt from Section 16b pursuant to Rule 16b-3(d)(1). The option is exercisable ratably monthly over a four (4) year period commencing November 20, 2004 (Reporting Person's date of hire, and thus such option is partially vested as of the grant date) and shall be fully vested on Novemer 20, 2008. /s/ Seth Horn 2005-08-18