X0304 4 2011-12-05 1 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001189539 BRYSON VAUGHN D 929 NORTH FRONT STREET WILMINGTON NC 28401 1 0 0 0 Common Stock 2011-05-18 4 D 0 1139 33.25 D 0 D Stock Options (to buy) 28.52 2011-12-05 4 D 0 9095 0 D Common Stock 9095 0 D Pursuant to the Agreement and Plan of Merger (the "Agreement") by and among Pharmaceutical Prodcut Development, Inc., Jaguar Holdings, LLC and Jaguar Merger Sub, Inc. dated as of October 2, 2011, on the effective date of the merger contemplated by the Agreement (the "Merger"), each of these shares of common stock was automatically converted into the right to receive $33.25. These stock options were cancelled pursuant to the Merger in exchange for a cash payment equal to the difference, if any,between the exercise price of the stock options and $33.25 multiplied by the number of shares subject to such stock options less any applicable withholding taxes. Lisa. C. Noecker, attorney-in-fact for Vaughn D. Bryson 2011-12-06