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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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<SEC-DOCUMENT>0001209191-05-035916.txt : 20050706
<SEC-HEADER>0001209191-05-035916.hdr.sgml : 20050706
<ACCEPTANCE-DATETIME>20050706215921
ACCESSION NUMBER:		0001209191-05-035916
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050701
FILED AS OF DATE:		20050706
DATE AS OF CHANGE:		20050706

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LIFEPOINT HOSPITALS, INC.
		CENTRAL INDEX KEY:			0001301611
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-GENERAL MEDICAL & SURGICAL HOSPITALS, NEC [8062]
		IRS NUMBER:				201538254
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		103 POWELL COURT
		STREET 2:		SUITE 200
		CITY:			BRENTWOOD
		STATE:			TN
		ZIP:			37027
		BUSINESS PHONE:		615-372-8500

	MAIL ADDRESS:	
		STREET 1:		103 POWELL COURT
		STREET 2:		SUITE 200
		CITY:			BRENTWOOD
		STATE:			TN
		ZIP:			37027

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Lakers Holding Corp.
		DATE OF NAME CHANGE:	20040826

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			MAUPIN JOHN E JR D D S
		CENTRAL INDEX KEY:			0001189149

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51251
		FILM NUMBER:		05942273

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		6153728500

	MAIL ADDRESS:	
		STREET 1:		103 POWELL COURT SUITE 200
		CITY:			BRENTWOOD
		STATE:			TN
		ZIP:			37027
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>g96185jem.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-07-01</periodOfReport>

    <issuer>
        <issuerCik>0001301611</issuerCik>
        <issuerName>LIFEPOINT HOSPITALS, INC.</issuerName>
        <issuerTradingSymbol>LPNT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001189149</rptOwnerCik>
            <rptOwnerName>MAUPIN JOHN E JR D D S</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>103 POWELL COURT SUITE 200</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BRENTWOOD</rptOwnerCity>
            <rptOwnerState>TN</rptOwnerState>
            <rptOwnerZipCode>37027</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2005-07-01</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3500</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>6496</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2005-07-01</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>346</value>
                    <footnoteId id="F2"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>50.5400</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>6842</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">These shares were granted to the reporting person on July 1, 2005 as a restricted stock award under the LifePoint Hospitals, Inc. Outside Directors Stock and Incentive Compensation Plan.  Generally, such shares will be forfeited in their entirety unless the reporting person continues to serve as a director of the Company on July 1, 2008.</footnote>
        <footnote id="F2">The reporting person elected to receive Deferred Stock Units payable in Common Stock in lieu of cash compensation for all, or a portion of, the annual retainer paid to outside directors.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ John E. Maupin, Jr.</signatureName>
        <signatureDate>2005-07-06</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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