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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 vZ7gB/3rHtXyPNsORe4G9g==

<SEC-DOCUMENT>0001225208-08-008778.txt : 20080516
<SEC-HEADER>0001225208-08-008778.hdr.sgml : 20080516
<ACCEPTANCE-DATETIME>20080516170615
ACCESSION NUMBER:		0001225208-08-008778
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080514
FILED AS OF DATE:		20080516
DATE AS OF CHANGE:		20080516

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LIFEPOINT HOSPITALS, INC.
		CENTRAL INDEX KEY:			0001301611
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-GENERAL MEDICAL & SURGICAL HOSPITALS, NEC [8062]
		IRS NUMBER:				201538254
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		103 POWELL COURT
		STREET 2:		SUITE 200
		CITY:			BRENTWOOD
		STATE:			TN
		ZIP:			37027
		BUSINESS PHONE:		615-372-8500

	MAIL ADDRESS:	
		STREET 1:		103 POWELL COURT
		STREET 2:		SUITE 200
		CITY:			BRENTWOOD
		STATE:			TN
		ZIP:			37027

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Lakers Holding Corp.
		DATE OF NAME CHANGE:	20040826

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			EZELL DEWITT JR
		CENTRAL INDEX KEY:			0001189141

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51251
		FILM NUMBER:		08843143

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		6153728500

	MAIL ADDRESS:	
		STREET 1:		103 POWELL COURT SUITE 200
		CITY:			BRENTWOOD
		STATE:			TN
		ZIP:			37027
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2008-05-14</periodOfReport>

    <issuer>
        <issuerCik>0001301611</issuerCik>
        <issuerName>LIFEPOINT HOSPITALS, INC.</issuerName>
        <issuerTradingSymbol>LPNT</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001189141</rptOwnerCik>
            <rptOwnerName>EZELL DEWITT JR</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>103 POWELL COURT</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 200</rptOwnerStreet2>
            <rptOwnerCity>BRENTWOOD</rptOwnerCity>
            <rptOwnerState>TN</rptOwnerState>
            <rptOwnerZipCode>37027</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common</value>
            </securityTitle>
            <transactionDate>
                <value>2008-05-14</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3500</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>30493</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">This deferred restricted stock award was granted to the reporting person under the LifePoint Hospitals, Inc. Outside Directors Stock and Incentive Compensation Plan, as amended.  Generally, the award will be forfeited in its entirety unless the reporting person continues to serve as a director of the Company on the date that is 6 months plus 1 day from the date of grant.  The award will be settled on the third anniversary of the date of grant.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>DeWitt  Ezell, Jr.</signatureName>
        <signatureDate>2008-05-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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