<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2019-09-16</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001770787</issuerCik>
        <issuerName>10x Genomics, Inc.</issuerName>
        <issuerTradingSymbol>TXG</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001189140</rptOwnerCik>
            <rptOwnerName>STUELPNAGEL JOHN R</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O 10X GENOMICS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>6230 STONERIDGE MALL ROAD</rptOwnerStreet2>
            <rptOwnerCity>PLEASANTON</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94588</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

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                    <value>See Footnote</value>
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        <derivativeTransaction>
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                <value>Series D Preferred Stock</value>
                <footnoteId id="F2"/>
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                <footnoteId id="F3"/>
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            <transactionDate>
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                <transactionCode>C</transactionCode>
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                <value></value>
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                <transactionPricePerShare>
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            <ownershipNature>
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                <natureOfOwnership>
                    <value>See Footnote</value>
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                <footnoteId id="F2"/>
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            <conversionOrExercisePrice>
                <footnoteId id="F3"/>
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                <value></value>
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                <transactionShares>
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                <transactionAcquiredDisposedCode>
                    <value>A</value>
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                <directOrIndirectOwnership>
                    <value>I</value>
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                <natureOfOwnership>
                    <value>See Footnote</value>
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    </derivativeTable>

    <footnotes>
        <footnote id="F1">Pursuant to a reclassification exempt under Rule 16b-7, each share of Class B Common Stock was reclassified into one share of Class A Common Stock immediately prior to the completion of the Issuer's initial public offering.</footnote>
        <footnote id="F2">Includes 146,875 shares that are subject to a right of repurchase by the Issuer that lapses over time in accordance with the terms of the stock option awards that were early exercised by the Reporting Person.</footnote>
        <footnote id="F3">The Series A-1 Preferred Stock, Series A-2 Preferred Stock, Series B Preferred Stock, Series C Preferred Stock and Series D Preferred Stock automatically converted into Class B Common Stock, on a one-for-one basis, immediately prior to the completion of the Issuer's initial public offering and had no expiration date. Each share of Class B Common Stock is convertible at any time at the option of the Reporting Person into one share of Class A Common Stock and has no expiration date. Additionally, each share of Class B Common Stock will convert automatically into one share of Class A Common Stock upon transfer, whether or not for value (subject to certain exceptions) and upon the occurrence of certain other events set forth in the Issuer's Amended and Restated Certificate of Incorporation.</footnote>
        <footnote id="F4">These shares are held by the John R. Stuelpnagel Trust, of which the Reporting Person is the sole trustee.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Eric S. Whitaker, as Attorney-in-Fact</signatureName>
        <signatureDate>2019-09-16</signatureDate>
    </ownerSignature>
</ownershipDocument>
