<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2009-09-30</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001405197</issuerCik>
        <issuerName>Talecris Biotherapeutics Holdings Corp.</issuerName>
        <issuerTradingSymbol>TLCR</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001189009</rptOwnerCik>
            <rptOwnerName>Lenehan James T</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TALECRIS BIOTHERAPEUTICS HOLDINGS</rptOwnerStreet1>
            <rptOwnerStreet2>P.O. BOX 110526 4101 RESEARCH COMMONS</rptOwnerStreet2>
            <rptOwnerCity>RESEARCH TRIANGLE PARK</rptOwnerCity>
            <rptOwnerState>NC</rptOwnerState>
            <rptOwnerZipCode>27709</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>136872</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Options (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.39</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2006-04-01</value>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <value>2015-11-10</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>527200</value>
                    <footnoteId id="F2"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Options (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>9.88</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2009-04-01</value>
            </exerciseDate>
            <expirationDate>
                <value>2018-04-21</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>12616</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Options (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>16.63</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2010-04-01</value>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <value>2019-03-27</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>7848</value>
                    <footnoteId id="F3"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The number of shares reflected in this row includes 42,392 shares that have not yet vested of the Issuer's common stock that were granted by the Issuer to the Reporting Person on December 6, 2006 and which will vest on March 31, 2010, subject to the Reporting Person's continuous service with the Issuer through that date, as detailed in a restricted stock award agreement by and between the Issuer and the Reporting Person, dated as of December 6, 2006.  Also includes an additional 3,616 shares that have not yet vested of the Issuer's common stock that were granted by the Issuer to the Reporting Person on March 27, 2009 and which will vest on April 1, 2010, subject to the Reporting Person's continuous service with the Issuer through that date, as detailed in a restricted stock award agreement by and between the Issuer and the Reporting Person, dated as of March 27, 2009.</footnote>
        <footnote id="F2">The securities being reported in this row are options to purchase the Issuer's common stock that were granted by the Issuer to the Reporting Person on November 10, 2005.  105,440 of these options have not vested and will vest and become exercisable on April 1, 2010, subject to the Reporting Person remaining a Key Person (as defined in the Issuer's 2005 Stock Option and Incentive Plan) with the Issuer through that date, as detailed in a stock option award agreement by and between the Issuer and the Reporting Person, dated as of November 10, 2005.</footnote>
        <footnote id="F3">The securities being reported in this row are options to purchase the Issuer's common stock that were granted by the Issuer to the Reporting Person on March 27, 2009.  These options will vest and become exercisable on April 1, 2010, subject to the Reporting Person remaining a Key Person (as defined in the Issuer's 2005 Stock Option and Incentive Plan) with the Issuer through that date, as detailed in a stock option award agreement by and between the Issuer and the Reporting Person, dated as of March 27, 2009.</footnote>
    </footnotes>

    <remarks>Exhibit List: Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ John F. Gaither, Jr., attorney in fact</signatureName>
        <signatureDate>2009-09-30</signatureDate>
    </ownerSignature>
</ownershipDocument>
