<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2021-12-02-05:00</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001187953</issuerCik>
        <issuerName>CREATIVE MEDICAL TECHNOLOGY HOLDINGS, INC.</issuerName>
        <issuerTradingSymbol>CELZ</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001898373</rptOwnerCik>
            <rptOwnerName>Urdang Bruce Steven</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>5171 E. HAWTHORNE DR.</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>FLAGSTAFF</rptOwnerCity>
            <rptOwnerState>AZ</rptOwnerState>
            <rptOwnerZipCode>86004-7377</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Bruce Steven Urdang</signatureName>
        <signatureDate>2021-12-13-05:00</signatureDate>
    </ownerSignature>
</ownershipDocument>
