<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001187342</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001492691</issuerCik>
      <issuerName>Knight-Swift Transportation Holdings, Inc.</issuerName>
      <secFileNumber>001-35007</secFileNumber>
      <issuerAddress>
        <com:street1>2002 West Wahalla Lane</com:street1>
        <com:city>Phoenix</com:city>
        <com:stateOrCountry>AZ</com:stateOrCountry>
        <com:zipCode>85027</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>602-269-9700</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Kevin P. Knight</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Executive Chairman</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>J.P. Morgan Securities LLC</name>
        <address>
          <com:street1>270 Park Avenue, 10th Floor</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10017</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>35000</noOfUnitsSold>
      <aggregateMarketValue>1785350</aggregateMarketValue>
      <noOfUnitsOutstanding>162339000</noOfUnitsOutstanding>
      <approxSaleDate>12/09/2025</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>08/20/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Transfer</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>From Kevin Knight, who acquired the shares from the Issuer on 01/31/25 though compensation</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>22987</amountOfSecuritiesAcquired>
      <paymentDate>08/20/2025</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>10/24/1994</acquiredDate>
      <natureOfAcquisitionTransaction>Founder Shares</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>12013</amountOfSecuritiesAcquired>
      <paymentDate>10/24/1994</paymentDate>
      <natureOfPayment>N/A</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>The shares covered by the filing will be sold by the Kevin and Sydney Knight Revocable Living Trust, Kevin P. Knight as Trustee.</remarks>
    <noticeSignature>
      <noticeDate>12/09/2025</noticeDate>
      <signature>/s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Kevin P. Knight</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
