X0304 4 2012-03-05 0000946840 VIROPHARMA INC VPHM 0001187172 DOYLE THOMAS F 730 STOCKTON DRIVE EXTON PA 19341 1 VP Strategic Initiatives Common Stock 2012-03-05 4 M 0 20000 3.93 A 72444 D Common Stock 2012-03-05 4 M 0 30000 2.09 A 102444 D Common Stock 2012-03-05 4 M 0 100000 3.55 A 202444 D Common Stock 2012-03-05 4 M 0 60000 3.14 A 262444 D Common Stock 2012-03-05 4 S 0 210000 32.4772 D 52444 D Employee Stock Option (Right to Buy) 3.93 2012-03-05 4 M 0 20000 0 D 2003-04-16 2012-04-16 Common Stock 20000 0 D Employee Stock Option (Right to Buy) 2.09 2012-03-05 4 M 0 30000 0 D 2004-07-22 2013-07-22 Common Stock 30000 0 D Non-qualified Stock Option (Right to Buy) 3.55 2012-03-05 4 M 0 100000 0 D 2005-01-15 2014-01-15 Common Stock 100000 0 D Employee Stock Option (Right to Buy) 3.14 2012-03-05 4 M 0 60000 0 D 2006-01-21 2015-01-21 Common Stock 60000 0 D The options vest in four equal annual installments beginning on the anniversary date from time of grant. The options vest in four equal annual installments beginning on the first anniversary date from time of grant. The price reported in Colum 4 is an average price. /s/ J. Peter Wolf, attorney-in-fact 2012-03-07