<?xml version="1.0" encoding="us-ascii"?><InstanceReport xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xsd="http://www.w3.org/2001/XMLSchema"><Version>2.2.0.25</Version><hasSegments>false</hasSegments><hasScenarios>false</hasScenarios><ReportLongName>0201 - Disclosure - Organization and Business</ReportLongName><DisplayLabelColumn>true</DisplayLabelColumn><ShowElementNames>false</ShowElementNames><RoundingOption /><HasEmbeddedReports>false</HasEmbeddedReports><Columns><Column><Id>1</Id><IsAbstractGroupTitle>false</IsAbstractGroupTitle><LabelColumn>false</LabelColumn><CurrencyCode>USD</CurrencyCode><FootnoteIndexer /><hasSegments>false</hasSegments><hasScenarios>false</hasScenarios><MCU><KeyName>1/1/2011 - 3/31/2011
USD ($)

USD ($) / shares
</KeyName><CurrencySymbol>$</CurrencySymbol><contextRef><ContextID>Jan-01-2011_Mar-31-2011</ContextID><EntitySchema>http://www.sec.gov/CIK</EntitySchema><EntityValue>0001185348</EntityValue><PeriodDisplayName /><PeriodType>duration</PeriodType><PeriodStartDate>2011-01-01T00:00:00</PeriodStartDate><PeriodEndDate>2011-03-31T00:00:00</PeriodEndDate><Segments /><Scenarios /></contextRef><UPS><UnitProperty><UnitID>USD</UnitID><UnitType>Standard</UnitType><StandardMeasure><MeasureSchema>http://www.xbrl.org/2003/iso4217</MeasureSchema><MeasureValue>USD</MeasureValue><MeasureNamespace>iso4217</MeasureNamespace></StandardMeasure><Scale>0</Scale></UnitProperty><UnitProperty><UnitID>Shares</UnitID><UnitType>Standard</UnitType><StandardMeasure><MeasureSchema>http://www.xbrl.org/2003/instance</MeasureSchema><MeasureValue>shares</MeasureValue><MeasureNamespace>xbrli</MeasureNamespace></StandardMeasure><Scale>0</Scale></UnitProperty><UnitProperty><UnitID>USDEPS</UnitID><UnitType>Divide</UnitType><NumeratorMeasure><MeasureSchema>http://www.xbrl.org/2003/iso4217</MeasureSchema><MeasureValue>USD</MeasureValue><MeasureNamespace>iso4217</MeasureNamespace></NumeratorMeasure><DenominatorMeasure><MeasureSchema>http://www.xbrl.org/2003/instance</MeasureSchema><MeasureValue>shares</MeasureValue><MeasureNamespace>xbrli</MeasureNamespace></DenominatorMeasure><Scale>0</Scale></UnitProperty></UPS><CurrencyCode>USD</CurrencyCode><OriginalCurrencyCode>USD</OriginalCurrencyCode></MCU><CurrencySymbol>$</CurrencySymbol><Labels><Label Id="1" Label="3 Months Ended" /><Label Id="2" Label="Mar. 31, 2011" /></Labels></Column></Columns><Rows><Row><Id>2</Id><IsAbstractGroupTitle>true</IsAbstractGroupTitle><Level>0</Level><ElementName>us-gaap_GeneralPoliciesAbstract</ElementName><ElementPrefix>us-gaap</ElementPrefix><IsBaseElement>true</IsBaseElement><BalanceType>na</BalanceType><PeriodType>duration</PeriodType><ShortDefinition>No definition available.</ShortDefinition><IsReportTitle>false</IsReportTitle><IsSegmentTitle>false</IsSegmentTitle><IsSubReportEnd>false</IsSubReportEnd><IsCalendarTitle>false</IsCalendarTitle><IsTuple>false</IsTuple><IsEquityPrevioslyReportedAsRow>false</IsEquityPrevioslyReportedAsRow><IsEquityAdjustmentRow>false</IsEquityAdjustmentRow><IsBeginningBalance>false</IsBeginningBalance><IsEndingBalance>false</IsEndingBalance><IsReverseSign>false</IsReverseSign><PreferredLabelRole /><FootnoteIndexer /><Cells><Cell><Id>1</Id><IsNumeric>false</IsNumeric><IsRatio>false</IsRatio><DisplayZeroAsNone>false</DisplayZeroAsNone><NumericAmount>0</NumericAmount><RoundedNumericAmount>0</RoundedNumericAmount><NonNumbericText /><NonNumericTextHeader /><FootnoteIndexer /><CurrencyCode /><CurrencySymbol /><IsIndependantCurrency>false</IsIndependantCurrency><ShowCurrencySymbol>false</ShowCurrencySymbol><DisplayDateInUSFormat>false</DisplayDateInUSFormat><hasSegments>false</hasSegments><hasScenarios>false</hasScenarios></Cell></Cells><OriginalInstanceReportColumns /><Unit>Other</Unit><ElementDataType>xbrli:stringItemType</ElementDataType><SimpleDataType>string</SimpleDataType><ElementDefenition>No definition available.</ElementDefenition><IsTotalLabel>false</IsTotalLabel><IsEPS>false</IsEPS><Label>Organization and Business [Abstract]</Label></Row><Row><Id>3</Id><IsAbstractGroupTitle>false</IsAbstractGroupTitle><Level>0</Level><ElementName>us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock</ElementName><ElementPrefix>us-gaap</ElementPrefix><IsBaseElement>true</IsBaseElement><BalanceType>na</BalanceType><PeriodType>duration</PeriodType><ShortDefinition>No definition available.</ShortDefinition><IsReportTitle>false</IsReportTitle><IsSegmentTitle>false</IsSegmentTitle><IsSubReportEnd>false</IsSubReportEnd><IsCalendarTitle>false</IsCalendarTitle><IsTuple>false</IsTuple><IsEquityPrevioslyReportedAsRow>false</IsEquityPrevioslyReportedAsRow><IsEquityAdjustmentRow>false</IsEquityAdjustmentRow><IsBeginningBalance>false</IsBeginningBalance><IsEndingBalance>false</IsEndingBalance><IsReverseSign>false</IsReverseSign><PreferredLabelRole>verboselabel</PreferredLabelRole><FootnoteIndexer /><Cells><Cell><Id>1</Id><IsNumeric>false</IsNumeric><IsRatio>false</IsRatio><DisplayZeroAsNone>false</DisplayZeroAsNone><NumericAmount>0</NumericAmount><RoundedNumericAmount>0</RoundedNumericAmount><NonNumbericText>&lt;!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --&gt;
   &lt;!-- Begin Block Tagged Note 1 - us-gaap:OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock--&gt;
   &lt;div align="left" style="font-family: 'Times New Roman',Times,serif"&gt;
   &lt;!-- xbrl,ns --&gt;
   &lt;!-- xbrl,nx --&gt;
   &lt;div align="center" style="font-size: 10pt; margin-top: 0pt"&gt;&lt;b&gt;&lt;/b&gt;
   &lt;/div&gt;
   &lt;div align="left"&gt;
   &lt;/div&gt;
   &lt;div align="center" style="font-size: 10pt"&gt;&lt;b&gt;&lt;/b&gt;&lt;/div&gt;
   &lt;div align="center" style="font-size: 10pt"&gt;&lt;b&gt;&lt;/b&gt;&lt;/div&gt;
   &lt;div align="left" style="font-size: 10pt; margin-top: 12pt"&gt;&lt;b&gt;1. Organization and Business:&lt;/b&gt;
   &lt;/div&gt;
   &lt;div align="left" style="font-size: 10pt; margin-top: 6pt"&gt;&amp;#160;&amp;#160;&amp;#160;&amp;#160;&amp;#160;Portfolio Recovery Associates, LLC (&amp;#8220;PRA&amp;#8221;) was formed on March&amp;#160;20, 1996. Portfolio Recovery
   Associates, Inc. (&amp;#8220;PRA Inc&amp;#8221;) was formed in August&amp;#160;2002. On November&amp;#160;8, 2002, PRA Inc completed its
   initial public offering (&amp;#8220;IPO&amp;#8221;) of common stock. In connection with the IPO, all of the membership
   units and warrants of PRA were exchanged on a one to one basis for shares of a single class of
   common stock of PRA Inc and warrants to purchase shares of PRA Inc common stock, respectively. PRA
   Inc owns all outstanding membership units of PRA, PRA Holding I, LLC (&amp;#8220;PRA Holding I&amp;#8221;), PRA Holding
   II, LLC (&amp;#8220;PRA Holding II&amp;#8221;), PRA Holding III, LLC (&amp;#8220;PRA Holding III&amp;#8221;), PRA Receivables Management,
   LLC (&amp;#8220;PRA Receivables Management&amp;#8221;), PRA Location Services, LLC (&amp;#8220;PLS&amp;#8221;) (formerly referred to as
   &amp;#8220;IGS&amp;#8221;), PRA Government Services, LLC (d/b/a RDS) (&amp;#8220;RDS&amp;#8221;) and MuniServices, LLC (d/b/a PRA
   Government Services) (&amp;#8220;MuniServices&amp;#8221;). On March&amp;#160;15, 2010, PRA Inc acquired 62% of the membership
   units of Claims Compensation Bureau, LLC (&amp;#8220;CCB&amp;#8221;). The business of PRA Inc, a Delaware corporation,
   and its subsidiaries (collectively, the &amp;#8220;Company&amp;#8221;) revolves around the detection, collection, and
   processing of both unpaid and normal-course receivables originally owed to credit grantors,
   governments, retailers and others. The Company&amp;#8217;s primary business is the purchase, collection and
   management of portfolios of defaulted consumer receivables. These accounts are purchased from
   sellers of finance receivables and collected by a highly skilled staff whose purpose is to locate
   and contact customers and arrange payment or resolution of their debts. The Company, through its
   Litigation Department, collects accounts judicially, either by using its own attorneys or by
   contracting with independent attorneys throughout the country through whom the Company takes legal
   action to satisfy consumer debts. The Company also services receivables on behalf of clients on
   either a commission or transaction-fee basis. Clients include entities in the financial services,
   auto, retail, utility, health care and government sectors. Services provided to these clients
   include obtaining location information for clients in support of their collection activities (known
   as skip tracing), and the management of both delinquent and non-delinquent receivables for
   government entities. In addition, through its CCB subsidiary, the Company provides class action
   claims settlement recovery services and related payment processing to its corporate clients.
   &lt;/div&gt;
   &lt;div align="left" style="font-size: 10pt; margin-top: 6pt"&gt;&amp;#160;&amp;#160;&amp;#160;&amp;#160;&amp;#160;The consolidated financial
    statements of the Company include the accounts of PRA Inc, PRA, PRA
   Holding I, PRA Holding II, PRA Holding III, PRA Receivables Management, PLS, RDS, MuniServices and
   CCB. Under the guidance of the Financial Accounting Standards Board
   (&amp;#8220;FASB&amp;#8221;) Accounting Standards Codification (&amp;#8220;ASC&amp;#8221;) Topic 280 &amp;#8220;Segment Reporting&amp;#8221; (&amp;#8220;ASC 280&amp;#8221;), the Company has
   determined that it has several operating segments that meet the aggregation criteria of ASC 280
   and, therefore, it has one reportable segment, accounts receivables management, based on similarities among
   the operating units, including homogeneity of services, service delivery methods and use of
   technology.
   &lt;/div&gt;
   &lt;div align="left" style="font-size: 10pt; margin-top: 6pt"&gt;&amp;#160;&amp;#160;&amp;#160;&amp;#160;&amp;#160;The accompanying unaudited consolidated financial statements of the Company have been prepared
   in accordance with Rule&amp;#160;10-01 of Regulation&amp;#160;S-X promulgated by the Securities and Exchange
   Commission (&amp;#8220;SEC&amp;#8221;) and, therefore, do not include all information and disclosures required by U.S.
   generally accepted accounting principles for complete financial statements. In the opinion of the
   Company, however, the accompanying unaudited consolidated financial statements contain all
   adjustments, consisting only of normal recurring adjustments, necessary for a fair presentation of
   the Company&amp;#8217;s consolidated balance sheet as of March&amp;#160;31, 2011, its consolidated income statements
   for the three months ended March&amp;#160;31, 2011 and 2010, its consolidated statement of changes in
   stockholders&amp;#8217; equity for the three months ended March&amp;#160;31, 2011, and its consolidated statements of
   cash flows for the three months ended March&amp;#160;31, 2011 and 2010. The consolidated income statement
   of the Company for the three months ended March&amp;#160;31, 2011 may not be indicative of future results.
   These unaudited consolidated financial statements should be read in conjunction with the audited
   consolidated financial statements and notes thereto included in the Company&amp;#8217;s Annual Report on Form
   10-K, as filed for the year ended December&amp;#160;31, 2010.
   &lt;/div&gt;
   &lt;/div&gt;
</NonNumbericText><NonNumericTextHeader>&lt;!--DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd" --&gt;
   &lt;!-- Begin Block Tagged Note</NonNumericTextHeader><FootnoteIndexer /><CurrencyCode /><CurrencySymbol /><IsIndependantCurrency>false</IsIndependantCurrency><ShowCurrencySymbol>false</ShowCurrencySymbol><DisplayDateInUSFormat>false</DisplayDateInUSFormat><hasSegments>false</hasSegments><hasScenarios>false</hasScenarios></Cell></Cells><OriginalInstanceReportColumns /><Unit>Other</Unit><ElementDataType>us-types:textBlockItemType</ElementDataType><SimpleDataType>string</SimpleDataType><ElementDefenition>Description containing the entire organization, consolidation and basis of presentation of financial statements disclosure. May be provided in more than one note to the financial statements, as long as users are provided with an understanding of (1) the significant judgments and assumptions made by an enterprise in determining whether it must consolidate a VIE and/or disclose information about its involvement with a VIE, (2) the nature of restrictions on a consolidated VIE's assets reported by an enterprise in its statement of financial position, including the carrying amounts of such assets, (3) the nature of, and changes in, the risks associated with an enterprise's involvement with the VIE, and (4) how an enterprise's involvement with the VIE affects the enterprise's financial position, financial performance, and cash flows.  Describes procedure if disclosures are provided in more than one note to the financial statements.</ElementDefenition><ElementReferences>Reference 1: http://www.xbrl.org/2003/role/presentationRef
 -Publisher FASB
 -Name FASB Staff Position (FSP)
 -Number FAS140-4 and FIN46(R)-8
 -Paragraph 8, C1, C7

Reference 2: http://www.xbrl.org/2003/role/presentationRef
 -Publisher AICPA
 -Name Accounting Research Bulletin (ARB)
 -Number 51
 -Paragraph 2-6

Reference 3: http://www.xbrl.org/2003/role/presentationRef
 -Publisher AICPA
 -Name Statement of Position (SOP)
 -Number 94-6
 -Paragraph 10

Reference 4: http://www.xbrl.org/2003/role/presentationRef
 -Publisher FASB
 -Name FASB Interpretation (FIN)
 -Number 46R
 -Paragraph 4, 14, 15

</ElementReferences><IsTotalLabel>false</IsTotalLabel><IsEPS>false</IsEPS><Label>Organization and Business:</Label></Row></Rows><Footnotes /><NumberOfCols>1</NumberOfCols><NumberOfRows>2</NumberOfRows><ReportName>Organization and Business</ReportName><MonetaryRoundingLevel>UnKnown</MonetaryRoundingLevel><SharesRoundingLevel>UnKnown</SharesRoundingLevel><PerShareRoundingLevel>UnKnown</PerShareRoundingLevel><ExchangeRateRoundingLevel>UnKnown</ExchangeRateRoundingLevel><HasCustomUnits>false</HasCustomUnits><SharesShouldBeRounded>true</SharesShouldBeRounded></InstanceReport>
