X0306 4 2017-10-16 0 0001359931 PROTEON THERAPEUTICS INC PRTO 0001185035 NOYES TIMOTHY P C/O PROTEON THERAPEUTICS 200 WEST STREET WALTHAM MA 02451 1 1 0 0 President and CEO Common Stock 2017-10-16 4 D 0 10000 2.312 D 38742 D The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 14, 2017. The selling price of $2.312 is reflective of the weighted average sale price of all transactions reported on this line. The prices for the transactions reported on this line range from $2.25 to $2.35. The reporting person undertakes to provide Proteon Therapeutics, Inc., any security holder of Proteon Therapeutics, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ George A. Eldridge as attorney-in-fact for Timothy P. Noyes 2017-10-17