X0203 3 2008-08-29 0 0001183765 THRESHOLD PHARMACEUTICALS INC THLDD 0001358990 HealthCare Ventures VIII, L.P. HEALTHCARE VENTURES LLC 44 NASSAU STREET PRINCETON NJ 08542 0 0 1 0 0001358991 HealthCare Partners VIII, L.P. HEALTHCARE VENTURES LLC 44 NASSAU STREET PRINCETON NJ 08542 0 0 1 0 0001358992 HealthCare Partners VIII, LLC HEALTHCARE VENTURES LLC 44 NASSAU STREET PRINCETON NJ 08542 0 0 1 0 0001013473 CAVANAUGH JAMES H HEALTHCARE VENTURES LLC 44 NASSAU STREET PRINCETON NJ 08542 0 0 1 0 0001013469 LITTLECHILD JOHN W 55 CAMBRIDGE PARKWAY SUITE 301 CAMBRIDGE MA 02142 0 0 1 0 0001013603 WERNER HAROLD R HEALTHCARE VENTURES LLC 44 NASSAU STREET PRINCETON NJ 08542 0 0 1 0 0001262326 Mirabelli Christopher 55 CAMBRIDGE PARKWAY SUITE 301 CAMBRIDGE MA 02142 0 0 1 0 0001262327 LAWLOR AUGUSTINE 55 CAMBRIDGE PARKWAY SUITE 301 CAMBRIDGE MA 02142 0 0 1 0 Common Stock 1470588 I and Direct Common Stock Warrants 2.34 2013-08-29 Common Stock 588235 I and Direct These securities are owned by HealthCare Ventures VIII, L.P. ("HCVVIII"). These securities are indirectly owned by HealthCare Partners VIII, L.P. ("HCPVIII"), the General Partner of HCVVIII, HealthCare Partners VIII, LLC (the "LLC"), the General Partner of HCPVIII, and each of James Cavanaugh, Harold Werner, John Littlechild, Christopher Mirabelli and Augustine Lawlor, the Managing Directors of the LLC. Drs. Cavanaugh and Mirabelli and Messrs. Werner, Littlechild and Lawlor disclaim beneficial ownership of those securities in which they do not have a pecuniary interest and this report shall not be deemed an admission that they are the beneficial owners of these securities for purposes of Section 16, except to the extent of their pecuniary interest therein. Immediately exercisable. /s/Jeffrey Steinberg, Administrative Officer HealthCare Ventures VIII, L.P. 2008-09-08 /s/Jeffrey Steinberg, Administrative Partner, HealthCare Partners VIII, L.P. 2008-09-08 /s/Jeffrey Steinberg, Administrative Officer, HeathCare Partners VIII, LLC 2008-09-08 /s/Jeffrey Steinberg, Attorney-in-Fact for James H. Cavanaugh 2008-09-08 /s/Jeffrey Steinberg, Attorney-in-Fact for John Littlechild 2008-09-08 /s/Jeffrey Steinberg, Attorney-in-Fact for Harold Werner 2008-09-08 /s/Jeffrey Steinberg, Attorney-in-Fact for Christopher Mirabelli 2008-09-08 /s/Jeffrey Steinberg, Attorney-in-Fact for Augustine Lawlor 2008-09-08