X0306 4/A 2019-11-25 2019-11-27 0 0001183765 Molecular Templates, Inc. MTEM 0001619884 Hirsch David C/O LONGITUDE CAPITAL PARTNERS III, LLC 2740 SAND HILL ROAD, SECOND FLOOR MENLO PARK CA 94025 1 0 1 0 Common Stock 2019-11-25 4 P 0 937500 8.00 A 4199035 I By Longitude Venture Partners III, L.P. These shares were purchased pursuant to an underwritten public offering. Includes 500 shares that were inadvertently omitted from the original Form 4. These shares are held by Longitude Venture Partners III, L.P. The Reporting Person is a member of Longitude Capital Partners III, LLC, the general partner of Longitude Venture Partners III, L.P., and may be deemed to share voting, investment and dispositive power over these shares. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. /s/ David Hirsch 2019-12-05