X0303 4 2010-05-10 0001099800 Edwards Lifesciences Corp EW 0001182467 Nevinny Corinne H ONE EDWARDS WAY IRVINE CA 92614 1 CVP & Pres., Global Ops Common Stock 2010-05-10 4 S 0 3000 101.17 D 19687 D Common Stock 2010-05-11 4 S 0 3000 99.75 D 16687 D This transaction was executed in multiple trades at prices ranging from $100.98 to $101.38. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. This Form 4 reflects changes in beneficial ownership only; it does not identify other securities of the Issuer beneficially owned by the reporting person. This amount includes quarterly acquisition of shares under the Edwards Lifesciences Corporation Employee Stock Purchase Plan as reflected on the most recent report of the plan administrator. This transaction was executed in multiple trades at prices ranging from $99.70 to $99.80. The price reported above reflects the weighted average sale price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. /s/ Denise E. Botticelli, Attorney-in-Fact 2010-05-11