X0306 4 2012-08-01 1 0000820237 GEN PROBE INC GPRO 0001181678 BROWN JOHN W GEN-PROBE INCORPORATED 10210 GENETIC CENTER DRIVE SAN DIEGO CA 92121 1 0 0 0 Common Stock 2012-08-01 4 D 0 13623 82.75 D 0 D Stock Option (Right to Buy) 47.78 2012-08-01 4 D 0 20000 34.97 D 2015-12-22 Common Stock 20000 0 D Stock Option (Right to Buy) 52.69 2012-08-01 4 D 0 10000 30.06 D 2013-05-18 Common Stock 10000 0 D Stock Option (Right to Buy) 54.09 2012-08-01 4 D 0 10000 28.66 D 2014-05-31 Common Stock 10000 0 D Stock Option (Right to Buy) 57.75 2012-08-01 4 D 0 7500 25.00 D 2015-05-15 Common Stock 7500 0 D Stock Option (Right to Buy) 43.24 2012-08-01 4 D 0 7500 39.51 D 2016-05-14 Common Stock 7500 0 D Stock Option (Right to Buy) 45.65 2012-08-01 4 D 0 7500 37.10 D 2017-05-13 Common Stock 7500 0 D Stock Option (Right to Buy) 82.87 2012-08-01 4 D 0 7500 0 D 2018-05-19 Common Stock 7500 0 D This stock option was canceled pursuant to the Agreement and Plan of Merger, dated as of April 29, 2012, by and among the Registrant, Hologic, Inc., and Gold Acquisition Corp. (the "Merger Agreement"), in exchange for a payment in cash, without interest and less the amount of any required tax withholding, equal to the product of: (i) the excess of $82.75 (the per share merger consideration pursuant to the Merger Agreement) over the exercise price of the option; and (ii) the number of shares of common stock of the Registrant underlying the stock option. In accordance with the terms of the Merger Agreement, this stock option was canceled for no value because the exercise price of the stock option exceeded the per share merger consideration of $82.75. /s/ Andrew S. Greenhalgh, Attorney-in-Fact 2012-08-02