X0303 4 2010-07-30 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001181157 KLEMA CATHY 200 CENTRAL PARK AVE. NEW YORK NY 10024 1 0 0 0 Common Stock 13844 D Stock Options (to buy) 24.26 2010-07-30 4 A 0 9090 0 A 2011-07-30 2020-07-30 Common Stock 9090 9090 D Stock Options (to buy) 24.52 2010-05-20 2020-05-20 Common Stock 10496 10496 D Stock Options (to buy) 19.19 2009-05-20 2019-05-20 Common Stock 14053 14053 D Stock Options (to buy) 13.12 2003-05-14 2013-05-13 Common Stock 8281 8281 D Stock Options (to buy) 32.67 2007-05-16 2017-05-15 Common Stock 6341 6341 D Stock Options (to buy) 34.18 2006-05-17 2016-05-16 Common Stock 4113 4113 D Stock Options (to buy) 14.55 2004-05-19 2014-05-18 Common Stock 16561 16561 D Stock Options (to buy) 22.98 2005-05-18 2015-05-17 Common Stock 5650 5650 D Stock Options (to buy) 41.32 2008-05-21 2018-05-20 Common Stock 6485 6485 D The options will vest in three equal increments on 7/30/11, 7/30/12 and 7/30/13. Exercise price and share amounts reflect an anti-dilution adjustment made in connection with the June 14, 2010 spin-off of Furiex Pharmaceuticals, Inc. Lisa C. Noecker attorney-in-fact for Catherine M. Klema 2010-08-02