X0303 4 2010-06-17 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001181156 HARTMAN JUDD 929 NORTH FRONT STREET WILMINGTON NC 28401 0 1 0 0 General Counsel Stock Options (to buy) 26.64 2010-06-17 4 A 0 25000 0 A 2011-06-17 2020-06-17 Common Stock 25000 25000 D Stock Options (to buy) 20.45 2011-02-25 2020-02-25 Common Stock 51753 51573 D Stock Options (to buy) 25.74 2010-02-18 2019-02-18 Common Stock 36227 36227 D Stock Options (to buy) 19.94 2009-11-20 2018-11-20 Common Stock 18632 18632 D Stock Options (to buy) 37.69 2009-10-03 2018-10-03 Common Stock 18632 18632 D Stock Options (to buy) 43.26 2009-02-20 2018-02-20 Common Stock 46630 46630 D Stock Options (to buy) 20.47 2005-11-16 2014-11-15 Common Stock 82805 82805 D Stock Options (to buy) 33.44 2007-02-22 2016-02-21 Common Stock 41403 41403 D Stock Options (to buy) 32.47 2008-02-21 2017-02-20 Common Stock 15526 15526 D This option vests in three equal increments on 6/17/11, 6/17/12 and 6/17/13. Exercise price and share amounts reflect an anti-dilution adjustment made in connection with the June 14, 2010 spin-off of Furiex Pharmaceuticals, Inc. This option vests in three equal increments on 2/25/11, 2/25/12 and 2/25/13. This option vests in three equal increments on 2/18/10, 2/18/11 and 2/18/12. This option vests in three increments of 6,000 on 11/20/09, 11/20/10 and 11/20/11 This option will vest in increments of 1/3 on 10/3/09, 10/3/10 and 10/3/11. This option will vest in three equal increments on 2/20/09, 2/20/10 and 2/20/11. This option was awarded on 11/16/04 and vests in four equal installments on 11/16/05, 11/16/06, 11/16/07 and 11/16/08. This option was awarded on 2/22/06 and vests in three equal installments on 2/22/07, 2/22/08 and 2/22/09. This option vests in three increments of 5,000 on 2/21/08, 2/21/09 and 2/21/10. Lisa C. Noecker attorney-in-fact for B. Judd Hartman 2010-06-18