144 0001180765 XXXXXXXX LIVE 0001612042 Ascendis Pharma A/S 001-36815 Tuborg Boulevard 12 Hellerup G7 DK - 2900 45-70-22-22-44 Jan Moller Mikkelsen CEO Officer American Depository Shares J.P. Morgan Securities LLC

270 Park Avenue 10th Floor New York NY 10017

100000 21085000 60689487 12/02/2025 NASDAQ American Depository Shares 12/02/2025 Warrant Exercise Issuer N 100000 12/02/2025 Cash Y The shares relate to warrants granted in 2015 and 2016 where expiry is upcoming. 12/02/2025 /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Jan Moller Mikkelsen