X0306 4 2018-05-10 0 0001117480 CHIMERIX INC CMRX 0001180469 MARIO ERNEST C/O CHIMERIX, INC. 2505 MERIDIAN PARKWAY, SUITE 100 DURHAM NC 27713 1 0 0 0 Common Stock 2018-05-10 4 S 0 2815 4.60 D 265720 I By The Ernest and Mildred Mario Revocable Trust, Ernest and Mildred Mario, Trustees Common Stock 12905 D The range of sale prices received is $4.59 to $4.61. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information will be provided regarding the number of shares purchased or sold at each separate price. /s/ Michael Alrutz, Attorney-in-Fact 2018-05-11