X0202 4 2007-05-07 0001003124 PHARMACEUTICAL PRODUCT DEVELOPMENT INC PPDI 0001180469 MARIO ERNEST 20 GREENHOUSE DRIVE PRINCETON NJ 08540 1 0 0 0 Common Stock 2007-05-07 4 S 0 100 35.08 D 445452 I Family Partnership Common Stock 2007-05-07 4 S 0 450 35.04 D 445002 I Family Partnership Common Stock 2007-05-07 4 S 0 400 35.01 D 444602 I Family Partnership Common Stock 2007-05-07 4 S 0 4450 35.00 D 440152 I Family Partnership Common Stock 2007-05-07 4 S 0 2000 34.67 D 438152 I Family Partnership Common Stock 2007-05-07 4 S 0 1000 34.66 D 437152 I Family Partnership Common Stock 2007-05-07 4 S 0 1000 34.65 D 436152 I Family Partnership Common Stock 2007-05-07 4 S 0 2000 34.64 D 434152 I Family Partnership Common Stock 2007-05-07 4 S 0 2000 34.63 D 432152 I Family Partnership Common Stock 2007-05-07 4 S 0 4000 34.62 D 428152 I Family Partnership Common Stock 2007-05-07 4 S 0 6000 34.61 D 422152 I Family Partnership Common Stock 2007-05-07 4 S 0 16000 34.59 D 406152 I Family Partnership Common Stock 2007-05-07 4 S 0 1000 34.58 D 405152 I Family Partnership Common Stock 2007-05-07 4 S 0 13000 34.57 D 392152 I Family Partnership Common Stock 2007-05-07 4 S 0 4000 34.56 D 388152 I Family Partnership Common Stock 2007-05-07 4 S 0 13000 34.55 D 375152 I Family Partnership Common Stock 2007-05-07 4 S 0 9000 34.54 D 366152 I Family Partnership Common Stock 2007-05-07 4 S 0 11000 34.53 D 355152 I Family Partnership Common Stock 2007-05-07 4 S 0 5000 34.52 D 350152 I Family Partnership Common Stock 2007-05-07 4 S 0 4600 34.51 D 345552 I Family Partnership Common Stock 341062 I By Spouse Common Stock 18500 I By Trust Common Stock 18500 I By Trust Common Stock 585015 D Stock Options (to buy) 5.97 1998-05-13 2008-05-12 Common Stock 16000 16000 D Stock Options (to buy) 6.25 1999-05-12 2009-05-11 Common Stock 16000 16000 D Stock Options (to buy) 15.82 2001-05-15 2011-05-14 Common Stock 8000 8000 D Stock Options (to buy) 12.81 2002-05-15 2012-05-14 Common Stock 12000 12000 D Stock Options (to buy) 13.58 2003-05-14 2013-05-13 Common Stock 16000 16000 D Stock Options (to buy) 15.06 2004-05-19 2014-05-18 Common Stock 16000 16000 D Stock Options (to buy) 23.79 2005-05-18 2015-05-17 Common Stock 5458 5458 D Stock Options (to buy) 35.38 2006-05-17 2016-05-16 Common Stock 3973 3973 D Lisa C. Noecker attorney-in-fact for Ernest Mario 2007-05-08