<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2021-01-27</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001827871</issuerCik>
        <issuerName>TLG Acquisition One Corp.</issuerName>
        <issuerTradingSymbol>TLGA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001180454</rptOwnerCik>
            <rptOwnerName>LAWRIE JOHN M</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O TLG ACQUISITION ONE CORP</rptOwnerStreet1>
            <rptOwnerStreet2>515 NORTH FLAGLER DRIVE, SUITE 520</rptOwnerStreet2>
            <rptOwnerCity>WEST PALM BEACH</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>33401</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>See Remarks</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Class F Common Stock, par value $0.0001</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <footnoteId id="F1"/>
                <footnoteId id="F3"/>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
                <footnoteId id="F2"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F1"/>
                <footnoteId id="F2"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Class A Common Stock, par value $0.0001</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>9814492</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                    <footnoteId id="F4"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnotes</value>
                    <footnoteId id="F1"/>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Represents 9,314,492 shares of Class F Common Stock held by TLG Acquisition Founder LLC (the &quot;Sponsor&quot;) and 500,000 shares of Class F Common Stock held by TLG Fund I, LP (&quot;TLG Fund I&quot;). The reporting person is the manager of the Sponsor and has sole voting and dispositive power over the shares held by the Sponsor.  The reporting person is the manager of the general partner of TLG Fund I, who has sole voting and dispositive power over the shares held by TLG Fund I.</footnote>
        <footnote id="F2">The reporting person disclaims beneficial ownership of all of the securities that are or may be beneficially owned by the Sponsor, TLG Fund I or any of its affiliates except to the extent of his pecuniary interest therein. Pursuant to Rule 16a-1(a)(4) under the Securities Exchange Act of 1934, as amended (the &quot;Exchange Act&quot;), this filing shall not be deemed an admission that the reporting person is, for purposes of Section 16 of the Exchange Act or otherwise, the beneficial owner of any equity securities of the Issuer for purposes of Section 16 of the Exchange Act or otherwise.</footnote>
        <footnote id="F3">The shares of Class F Common Stock are convertible into shares of Class A Common Stock as described under the heading &quot;Description of Securities-Founder Shares&quot; in the Issuer's registration statement on Form S-1 (File No. 333-252032). The shares of Class F Common Stock have no expiration date.</footnote>
        <footnote id="F4">Includes 1,250,000 shares of Class F Common Stock that are subject to forfeiture depending on the extent to which the underwriters' over-allotment option is exercised.</footnote>
    </footnotes>

    <remarks>Chief Executive Officer and President

See Exhibit 24.1 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Juan Pablo Lopez as attorney-in-fact</signatureName>
        <signatureDate>2021-01-27</signatureDate>
    </ownerSignature>
</ownershipDocument>
