X0306 4 2019-05-29 0 0001439222 AGIOS PHARMACEUTICALS INC AGIO 0001180432 MARAGANORE JOHN C/O AGIOS PHARMACEUTICALS, INC. 88 SIDNEY STREET CAMBRIDGE MA 02139 1 0 0 0 Common stock 2019-05-31 4 M 0 1400 A 37609 D Stock option (right to buy) 47.91 2019-05-29 4 A 0 8919 0.00 A 2029-05-29 Common stock 8919 8919 D Restricted stock units 2019-05-29 4 A 0 1878 0.00 A Common stock 1878 1878 D Restricted stock units 2019-05-31 4 M 0 1400 0.00 D Common stock 1400 0 D Each restricted stock unit represents a contingent right to receive one share of the issuer's common stock. This option was granted on May 29, 2019. The shares underlying this option vest as to 100% of the underlying shares on May 29, 2020. The restricted stock units were granted on May 29, 2019. The shares underlying the stock units will vest in full on May 29, 2020. Vested shares will be delivered to the reporting person within three business days after such shares become vested. The restricted stock units were granted on May 31, 2018. The shares underlying the stock units vested in full on May 31, 2019. Vested shares will be delivered to the reporting person within three business days after such shares become vested. /s/ William Cook, as Attorney-in-fact for John Maraganore 2019-05-31