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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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 wvUfsZpMLSyIY6pN9iiJBw==

<SEC-DOCUMENT>0000898432-05-000320.txt : 20050411
<SEC-HEADER>0000898432-05-000320.hdr.sgml : 20050411
<ACCEPTANCE-DATETIME>20050411210043
ACCESSION NUMBER:		0000898432-05-000320
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20050330
FILED AS OF DATE:		20050411
DATE AS OF CHANGE:		20050411

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			MELAS KYRIAZI THEO
		CENTRAL INDEX KEY:			0001216078

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-50505
		FILM NUMBER:		05745068

	MAIL ADDRESS:	
		STREET 1:		81 WYMAN ST
		STREET 2:		POST OFFICE BOX 9046
		CITY:			WALTHAM
		STATE:			MA
		ZIP:			02454

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Cyberkinetics Neurotechnology Systems, Inc.
		CENTRAL INDEX KEY:			0001180253
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				134287300
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		SUITE 240
		STREET 2:		100 FOXBOROUGH BLVD.
		CITY:			FOXBOROUGH
		STATE:			MA
		ZIP:			02035
		BUSINESS PHONE:		508-549-9981

	MAIL ADDRESS:	
		STREET 1:		SUITE 240
		STREET 2:		100 FOXBOROUGH BLVD.
		CITY:			FOXBOROUGH
		STATE:			MA
		ZIP:			02035

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	TRAFALGAR VENTURES INC
		DATE OF NAME CHANGE:	20020814
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>cns-melaskyriazi_4ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2005-03-30</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001180253</issuerCik>
        <issuerName>Cyberkinetics Neurotechnology Systems, Inc.</issuerName>
        <issuerTradingSymbol>CYKN.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001216078</rptOwnerCik>
            <rptOwnerName>MELAS KYRIAZI THEO</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CYBERKINETICS NEUROTECHNOLOGY,</rptOwnerStreet1>
            <rptOwnerStreet2>100 FOXBOROUGH BLVD. STE 240</rptOwnerStreet2>
            <rptOwnerCity>FOXBOROUGH</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02035</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>STOCK OPTION</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>2.25</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2005-03-30</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>5000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2015-03-29</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>COMMON STOCK</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>5000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>5000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The options vest 6.25% per quarter over 4 years beginning on June 30, 2005.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Theo Melas-Kyriazi</signatureName>
        <signatureDate>2005-04-11</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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